Prediction of Acute Radiation Mucositis using an Oral Mucosal Dose Surface Model in Carbon Ion Radiotherapy for Head and Neck Tumors.
Prediction of Acute Radiation Mucositis using an Oral Mucosal Dose Surface Model in Carbon Ion Radiotherapy for Head and Neck Tumors.
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DOI：
10.1371/journal.pone.0141734
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Nakano T
中科院分区：
文献类型：
--
作者：
Musha A;Shimada H;Shirai K;Saitoh J;Yokoo S;Chikamatsu K;Ohno T;Nakano T
采用口腔粘膜剂量面模型（OMDS模型）评价头颈部肿瘤碳离子放疗（C-ion RT）中急性放射性粘膜炎（ARM）发生的剂量-反应关系。根据不良事件通用术语标准（CTCAE）第4.0版和放射治疗肿瘤学组（RTOG）评分系统，对39例接受C-离子RT治疗头颈部癌症的患者进行了ARM评价（每周一次，持续6周）。通常使用的照射时间表为64戈伊[相对生物学有效性（RBE）]，分16次照射4周。在每例患者中，将腭和舌中的最大点剂量与ARM进行比较。ARM的位置与OMDS模型中的高剂量区一致。最大点剂量与使用RTOG标准而非CTCAE评估的ARM分级之间存在明确的剂量-反应关系。腭部和舌部2-3级ARM的阈值剂量分别为43.0戈伊（RBE）和54.3戈伊（RBE）。OMDS模型可用于预测ARM的部位和严重程度，模型中的最大点剂量与2-3级ARM相关良好。
To evaluate the dose-response relationship for development of acute radiation mucositis (ARM) using an oral mucosal dose surface model (OMDS-model) in carbon ion radiotherapy (C-ion RT) for head and neck tumors. Thirty-nine patients receiving C-ion RT for head and neck cancer were evaluated for ARM (once per week for 6 weeks) according to the Common Terminology Criteria for Adverse Events (CTCAE), version 4.0, and the Radiation Therapy Oncology Group (RTOG) scoring systems. The irradiation schedule typically used was 64 Gy [relative biological effectiveness (RBE)] in 16 fractions for 4 weeks. Maximum point doses in the palate and tongue were compared with ARM in each patient. The location of the ARM coincided with the high-dose area in the OMDS-model. There was a clear dose-response relationship between maximum point dose and ARM grade assessed using the RTOG criteria but not the CTCAE. The threshold doses for grade 2–3 ARM in the palate and tongue were 43.0 Gy(RBE) and 54.3 Gy(RBE), respectively. The OMDS-model was useful for predicting the location and severity of ARM. Maximum point doses in the model correlated well with grade 2–3 ARM.