Immune Curbing of Cancer Stem Cells by CTLs Directed to NANOG.
Immune Curbing of Cancer Stem Cells by CTLs Directed to NANOG.
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DOI：
10.3389/fimmu.2018.01412
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发表时间：
2018
影响因子：
7.3
通讯作者：
Torensma R
中科院分区：
文献类型：
--
作者：
Wefers C;Schreibelt G;Massuger LFAG;de Vries IJM;Torensma R
Cancer stem cells (CSCs) have been identified as the source of tumor growth and disease recurrence. Eradication of CSCs is thus essential to achieve durable responses, but CSCs are resistant to current anti-tumor therapies. Novel therapeutic approaches that specifically target CSCs will, therefore, be crucial to improve patient outcome. Immunotherapies, which boost the body’s own immune system to eliminate cancerous cells, could be an alternative approach to target CSCs. Vaccines of dendritic cells (DCs) loaded with tumor antigens can evoke highly specific anti-tumor T cell responses. Importantly, DC vaccination also promotes immunological memory formation, paving the way for long-term cancer control. Here, we propose a DC vaccination that specifically targets CSCs. DCs loaded with NANOG peptides, a protein required for maintaining stem cell properties, could evoke a potent anti-tumor immune response against CSCs. We hypothesize that the resulting immunological memory will also control newly formed CSCs, thereby preventing disease recurrence.
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PD-L1通过维持PI3K/AKT途径激活来促进乳腺癌干细胞中的Oct4和Nanog表达。
影响因子：
6.4
作者：
Almozyan S;Colak D;Mansour F;Alaiya A;Al-Harazi O;Qattan A;Al-Mohanna F;Al-Alwan M;Ghebeh H
通讯作者：
Ghebeh H
影响因子：
8.8
作者：
Arteaga, M. F.;Mikesch, J-H;Fung, T-K;So, C. W. E.
通讯作者：
So, C. W. E.
影响因子：
3.4
作者：
Fairbanks DJ;Maughan PJ
通讯作者：
Maughan PJ
DOI：
10.1084/jem.179.3.1005
发表时间：
1994-03-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bakker AB;Schreurs MW;de Boer AJ;Kawakami Y;Rosenberg SA;Adema GJ;Figdor CG
通讯作者：
Figdor CG
影响因子：
5.2
作者：
Chang, David F.;Tsai, Steven C.;Lutzko, Carolyn
通讯作者：
Lutzko, Carolyn