Lectins and toxins in the plant diet of Phlebotomus papatasi (Diptera: Psychodidae) can kill Leishmania major promastigotes in the sandfly and in culture.
Lectins and toxins in the plant diet of Phlebotomus papatasi (Diptera: Psychodidae) can kill Leishmania major promastigotes in the sandfly and in culture.
复制标题
白蛉（双翅目：Psychodidae）植物饮食中的凝集素和毒素可以杀死白蛉和培养物中的利什曼原虫主要前鞭毛体。
DOI：
10.1080/00034989958348
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发表时间：
1999
影响因子：
--
通讯作者：
Schlein,Y
中科院分区：
文献类型：
--
作者：
Jacobson,RL;Schlein,Y
利什曼原虫主要前鞭毛体在白蛉以其自然栖息地中发现的一些植物为食后，在其载体帕帕塔斯白蛉中凝集并死亡。在体外试验中，蓖麻（Euphorbiaceae）、刺山柑（Capparis spinosa）、羊栖菜（Prosopis farcta）和柽柳（Tamarix nilotica）的提取物对寄生虫有凝集和杀灭作用。这种活性可被特定的碳水化合物抑制，表明这是提取物中各种凝集素的结果。在相似条件下，茄科植物茄（Solanum luteum）的提取物可裂解前鞭毛体，并且这种细胞毒性不会因所测试的糖而减弱。感染的果蝇在摄取了红毛蝇提取物后，前鞭毛体的死亡率很高。communis，即使当喂给果蝇的提取物已经与葡萄糖预混合时，葡萄糖是一种碳水化合物，其抑制由这种体外提取引起的凝集。结果表明，在L.主疫源地可以减少寄生虫的传播。
Leishmania majorpromastigotes are agglutinated and die in their vector,Phlebotomus papatasi, after the sandflies feed on some plants that are found in their natural habitat. In in-vitro assays, extracts ofRicinus communis(Euphorbiaceae),Capparis spinosa(Capparaceae),Prosopis farcta(Mimosaceae) andTamarix nilotica(Tamaricaceae) agglutinated and killed the parasites. This activity could be inhibited by specific carbohydrates, indicating that it was the result of various lectins in the extracts. An extract ofSolanum luteum(Solanaceae) lysed the promastigotes under similar conditions and this cytotoxicity was not abated by the sugars tested. High mortality of promastigotes occurred in infected flies after they ingested an extract ofR. communis, even when the extract fed to the flies had been pre-mixed with glucose, a carbohydrate that inhibited the agglutination caused by such an extractin vitro. The results indicate that the lectins and toxins found in the vegetation inL. majorfoci may decrease the transmission of the parasite.