RNA on the brain: emerging layers of post-transcriptional regulation in cerebral cortex development.
RNA on the brain: emerging layers of post-transcriptional regulation in cerebral cortex development.
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DOI：
10.1002/wdev.290
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Silver DL
中科院分区：
文献类型：
--
作者：
Lennox AL;Mao H;Silver DL
胚胎发育是大脑神经元产生和组织的关键时期。在发育中的大脑皮层中，这需要神经祖细胞增殖、神经元分化和迁移的复杂过程。每一步都依赖于基因表达的高度调控。特别是，RNA剪接，稳定性，定位和翻译已经成为小鼠皮质生成的关键转录后调控节点。RNA代谢的反式调节因子，包括microRNA（miR）和RNA结合蛋白（RBP），协调皮质发育的不同步骤。这些反式因子单独或协同作用影响RNA，通常是类似的类别，称为RNA调节子。新的技术进步提高了对发育中的新皮层中的转录后控制的日益复杂的理解的潜力。许多RNA结合因子也与皮质的神经发育疾病有关。因此，阐明RBP和miR如何会聚以影响祖细胞和神经元中的mRNA表达，将对皮质发育和疾病的机制提供有价值的见解。
Embryonic development is a critical period during which neurons of the brain are generated and organized. In the developing cerebral cortex, this requires complex processes of neural progenitor proliferation, neuronal differentiation, and migration. Each step relies upon highly regulated control of gene expression. In particular, RNA splicing, stability, localization, and translation have emerged as key post-transcriptional regulatory nodes of mouse corticogenesis. Trans-regulators of RNA metabolism, including microRNAs (miRs) and RNA-binding proteins (RBPs), orchestrate diverse steps of cortical development. These trans-factors function either individually or cooperatively to influence RNAs, often of similar classes, termed RNA regulons. New technological advances raise the potential for an increasingly sophisticated understanding of post-transcriptional control in the developing neocortex. Many RNA-binding factors are also implicated in neurodevelopmental diseases of the cortex. Therefore, elucidating how RBPs and miRs converge to influence mRNA expression in progenitors and neurons will give valuable insights into mechanisms of cortical development and disease.
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