Cocaine use, abuse and dependence in a population-based sample of female twins
Cocaine use, abuse and dependence in a population-based sample of female twins
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DOI：
10.1192/bjp.173.4.345
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发表时间：
1998-10-01
影响因子：
10.5
通讯作者：
Prescott, CA
中科院分区：
文献类型：
--
作者：
Kendler, KS;Prescott, CA
背景尽管在过去的半个世纪里，女性可卡因的使用有了显著的增长，但我们对女性可卡因使用和滥用的病因学知之甚少，对遗传因素的作用也几乎一无所知。结果可卡因使用、滥用和依赖的终生流行率分别为14.0%、3.3%和2.3%。在MZ和DZ双胞胎中，Probandwise一致率分别为：可卡因使用54%和42%;可卡因滥用47%和8%，可卡因依赖35%和0%。在MZ和DZ双胞胎中，优势比分别为：可卡因使用14.2和6.7，可卡因滥用40.8和2.7生物统计学模型拟合表明，可卡因使用倾向的相似性是由于遗传和家庭环境因素，而可卡因滥用和依赖症状的双胞胎相似性仅是由于遗传因素。估计的遗传力为：可卡因使用0.39，可卡因滥用0.79，依赖症状0.65。结论遗传因素对可卡因使用易感性，尤其是女性可卡因滥用和依赖易感性有重要影响。
Background Although cocaine use in women has increased substantially over the past half-century, we understand little about the aetiology in women of cocaine use and abuse, and know almost nothing about the role of genetic factors.Method We obtained by telephone interview a history of lifetime cocaine use, abuse and dependence from 1934 individual twins from female-female pairs ascertained through a population-based registry, including both members of 485 monozygotic (MZ) and 335 dizygotic (DZ) pairs.Results The prevalence of lifetime cocaine use, abuse and dependence were 14.0%, 3.3% and 2.3%. Probandwise concordance rates, in MZ and DZ twins, respectively were: cocaine use 54% and 42%; cocaine abuse 47% and 8% and cocaine dependence 35% and 0%. In MZ and DZ twins, odds ratios were: cocaine use 14.2 and 6.7 and cocaine abuse 40.8 and 2.7 Biometrical model-fitting suggested that win resemblance for liability to cocaine use was due to both genetic and familial - environmental factors while twin resemblance for cocaine abuse and symptoms of dependence was due solely to genetic factors. Estimated heritabilities were: cocaine use 0.39, cocaine abuse 0.79 and symptoms of dependence 0.65.Conclusions The vulnerability to cocaine use and particularly cocaine abuse and dependence in women is substantially influenced by genetic factors.