Hypertension associated with venous thromboembolism in patients with newly diagnosed lung cancer.
Hypertension associated with venous thromboembolism in patients with newly diagnosed lung cancer.
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初诊肺癌患者高血压与静脉血栓栓塞相关
DOI：
10.1038/srep19603
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发表时间：
2016-01-22
影响因子：
4.6
通讯作者：
China Venous Thromboembolism VTE Study Group
中科院分区：
文献类型：
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作者：
Zhang Y;Yang Y;Chen W;Liang L;Zhai Z;Guo L;Wang C;China Venous Thromboembolism VTE Study Group
本研究的目的是评估肺癌患者心血管疾病（CVD）风险因素与静脉血栓栓塞（VTE）发生之间的相关性，这可能有助于估计个体的静脉血栓栓塞风险。共632例新诊断肺癌的COPD患者在招募前3个月内进行了VTE调查，并在基线检查时评估了其主要CVD危险因素。632例患者中有86例（13.6%）发生了VTE事件。对年龄、性别、吸烟、体重指数、糖尿病、血脂异常、高血压和白色血细胞计数进行多因素logistic回归分析，发现高血压（OR 1.8; 95% CI 1.0-3.3）和白细胞增多（OR 2.7; 95%CI 1.5-4.8）与不同肿瘤组织学模型中的VTE显著相关，（OR 1.9; 95% CI 1.1-3.4）和白细胞增多（OR 2.7; 95% CI 1.5-4.7）也与不同肿瘤分期模型中的VTE显著相关。白细胞增多与高血压和静脉血栓栓塞呈线性相关（趋势P = 0.006），静脉血栓栓塞的OR随白细胞增多而增加（趋势P均<0.05）。总之，高血压增加了新诊断肺癌患者发生VTE的风险，这可能是由炎症介导的。
The aim of this study was to evaluate associations between cardiovascular disease (CVD) risk factors and the occurrence of venous thromboembolism (VTE) in patients with lung cancer that might help estimate an individual’s risk for VTE. A total of 632 unselected patients with newly diagnosed lung cancer were investigated for VTE within the three months prior to recruitment, and their major CVD risk factors were assessed at the baseline examination. Eighty-six of the 632 (13.6%) developed a VTE event. Multivariate logistic regression analysis, including age, sex, smoking, body mass index, diabetes, dyslipidemia, hypertension and white blood cell count, found that hypertension (OR 1.8; 95% CI 1.0–3.3) and leukocytosis (OR 2.7; 95% CI 1.5–4.8) were significantly associated with VTE in different tumor histology models and that hypertension (OR 1.9; 95% CI 1.1–3.4) and leukocytosis (OR 2.7; 95% CI 1.5–4.7) were also significantly associated with VTE in different tumor stage models. Leukocytosis was linearly associated with hypertension and VTE (P for trend = 0.006), and the ORs for VTE increased with leukocytosis (all P for trend <0.05). In conclusion, hypertension increased the risk of VTE in patients with newly diagnosed lung cancer, which may be mediated by the presence of inflammation.