A population-based study of the association between betel-quid chewing and the metabolic syndrome in men
A population-based study of the association between betel-quid chewing and the metabolic syndrome in men
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DOI：
10.1093/ajcn/83.5.1153
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发表时间：
2006-05-01
影响因子：
7.1
通讯作者：
Chen, Tony Hsiu-Hsi
中科院分区：
文献类型：
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作者：
Yen, Amy Ming-Fang;Chiu, Yueh-Hsia;Chen, Tony Hsiu-Hsi
背景：咀嚼槟榔是口咽部恶性肿瘤的公认危险因素，与高血糖和肥胖有关。与代谢综合征的其他特征的相关性尚未被报道。目的：这项研究在一项以人群为基础的研究中考察了咀嚼槟榔与代谢综合征的关系，允许识别的危险因素并探索剂量-反应效应。设计：2001-2003年间，在基隆社区综合筛查计划中招募的咀嚼槟榔和不咀嚼槟榔的男性(n=19839)中，研究了代谢综合征的特定年龄患病率。结果：年龄调整后的代谢综合征患病率，当前咀嚼者最高(25.13%)，前咀嚼者次之(22.04%)，非咀嚼者最低(15.73%)(P<；0.0001)。调整了其他重要的相关因素，如高血压和糖尿病家族史，以前咀嚼和现在咀嚼的人患代谢综合征的优势比(95%CI)分别为1.38(1.19，1.60)和1.78(1.53，2.08)。代谢综合征部分有意义的优势比范围从高血糖的1.24(95%CI：1.09，1.64)到高三酰甘油血症的1.90(95%CI：1.66，2.19)。结论：在对公认的危险因素进行调整后，我们的研究在一项以人群为基础的研究中显示，咀嚼槟榔对代谢综合征及其组成部分具有独立的预测剂量反应效应。
Background: Betel-quid chewing, an established risk factor for oropharyngeal malignancy, is associated with hyperglycemia and obesity. Associations with other characteristics of the metabolic syndrome have not been reported.Objective: This study examined associations between betel-quid chewing and the metabolic syndrome, allowing for recognized risk factors and exploring dose-response effects in a population-based study.Design: Age-specific prevalence rates of the metabolic syndrome were examined in betel-quid chewing and nonchewing men (n = 19 839) recruited into the Keelung Community-based Integrated Screening program in 2001-2003. The independent effect of betel-quid chewing on metabolic syndrome risk was examined by using multiple logistic regression with control for well-recognized risk factors (eg, education, physical activity, and dietary factors) and dose-response effects were examined by using trend tests.Results: The age-adjusted prevalence of the metabolic syndrome was highest in current chewers (25.13%), next highest in ex-chewers (22.04%), and lowest in nonchewers (15.73%) (P < 0.0001). Odds ratios (95% CIs) for the metabolic syndrome were 1.38 (1.19, 1.60) and 1.78 (1.53, 2.08) in ex-chewers and current chewers, respectively, adjusted for other significant correlates such as a family history of hypertension and diabetes mellitus. Meaningful odds ratios for the metabolic syndrome components ranged from 1.24 for hyperglycemia (95% CI: 1.09,1.64) to 1.90 (95% CI: 1.66,2.19) for hypertriacylglycerolemia. Increasing odds ratios for the metabolic syndrome with higher consumption of betel quid (whether by rate of use, duration of use, or cumulative exposure) suggest dose-response effects.Conclusions: After adjustment for well-established risk factors, our study showed independent predictive dose-response effects of betel-quid chewing for the metabolic syndrome and its components in a population-based study of men with a 15% prevalence of betel-nut chewing.