TRANSCUTANEOUS FOCAL ELECTRICAL STIMULATION VIA CONCENTRIC RING ELECTRODES REDUCES SYNCHRONY INDUCED BY PENTYLENETETRAZOLE IN BETA AND GAMMA BANDS IN RATS
TRANSCUTANEOUS FOCAL ELECTRICAL STIMULATION VIA CONCENTRIC RING ELECTRODES REDUCES SYNCHRONY INDUCED BY PENTYLENETETRAZOLE IN BETA AND GAMMA BANDS IN RATS
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DOI：
10.1142/s0129065711002729
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发表时间：
2011-04-01
影响因子：
8
通讯作者：
Koka, Kanthaiah
中科院分区：
文献类型：
--
作者：
Besio, Walter G.;Liu, Xiang;Koka, Kanthaiah
癫痫是一种神经系统疾病，影响着世界大约百分之一的人口。 25% 至 30% 的病例中抗癫痫药物无效。控制癫痫发作的电刺激可能是一种附加疗法。在用戊四唑诱导癫痫发作后，我们通过同心环电极在大鼠头皮上应用无创经皮局灶性电刺激（TFES）。我们发现癫痫发作期间 β-γ 频带内的同步性显着增加，并且 TFES 显着降低了 β-γ 活动的同步性并增加了 δ 频带的同步性。
Epilepsy is a neurological disorder that affects approximately one percent of the world population. Antiepileptic drugs are ineffective in 25 similar to 30% of cases. Electrical stimulation to control seizures may be an additive therapy. We applied noninvasive transcutaneous focal electrical stimulation (TFES) via concentric ring electrodes on the scalp of rats after inducing seizures with pentylenetetrazole. We found a significant increase in synchrony within the beta-gamma bands during seizures and that TFES significantly reduced the synchrony of the beta-gamma activity and increased synchrony in the delta band.