Early Endosome Morphology in Health and Disease.
Early Endosome Morphology in Health and Disease.
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DOI：
10.1007/978-3-319-75402-4_41
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发表时间：
2018
影响因子：
--
通讯作者：
Lakkaraju A
中科院分区：
文献类型：
--
作者：
Kaur G;Lakkaraju A
早期内体是从细胞外环境接收大分子和溶质的细胞器。早期内体的主要功能是将这些货物分类到细胞的回收和降解区室中。货物的降解涉及早期内体成熟为晚期内体，后者在获得水解酶后形成溶酶体。内体成熟涉及将特定蛋白质和脂质募集到早期内体膜，从而驱动内体形态的变化。早期内体成熟的缺陷通常伴随着形态的改变，例如体积和/或数量的增加。在阿尔茨海默氏病和 C 型尼曼皮克病中观察到早期内体增大，这些疾病也表现出内吞分选缺陷。本文讨论了调节早期内体形态的机制，并强调了内体成熟在视网膜色素上皮中的潜在重要性。
Early endosomes are organelles that receive macromolecules and solutes from the extracellular environment. The major function of early endosomes is to sort these cargos into recycling and degradative compartments of the cell. Degradation of the cargo involves maturation of early endosomes into late endosomes, which, after acquisition of hydrolytic enzymes, form lysosomes. Endosome maturation involves recruitment of specific proteins and lipids to the early endosomal membrane, which drives changes in endosome morphology. Defects in early endosome maturation are generally accompanied by alterations in morphology, such as increase in volume and/or number. Enlarged early endosomes have been observed in Alzheimer’s disease and Niemann Pick Disease type C, which also exhibit defects in endocytic sorting. This article discusses the mechanisms that regulate early endosome morphology and highlights the potential importance of endosome maturation in the retinal pigment epithelium.
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影响因子：
64.5
作者：
Horiuchi, H;Lippe, R;Zerial, M
通讯作者：
Zerial, M
影响因子：
7.2
作者：
Maxfield, Frederick R.
通讯作者：
Maxfield, Frederick R.
影响因子：
21.3
作者：
Kobayashi, T;Beuchat, MH;Gruenberg, J
通讯作者：
Gruenberg, J
DOI：
10.1083/jcb.109.6.3303
发表时间：
1989-12
期刊：
The Journal of cell biology
影响因子：
--
作者：
Dunn KW;McGraw TE;Maxfield FR
通讯作者：
Maxfield FR
影响因子：
11.4
作者：
Mattera, Rafael;Bonifacino, Juan S.
通讯作者：
Bonifacino, Juan S.