INFLUENCE OF INSULIN RESISTANCE, SECRETION, AND CLEARANCE ON SERUM-CHOLESTEROL, TRIGLYCERIDES, LIPOPROTEIN CHOLESTEROL, AND BLOOD-PRESSURE IN HEALTHY-MEN
INFLUENCE OF INSULIN RESISTANCE, SECRETION, AND CLEARANCE ON SERUM-CHOLESTEROL, TRIGLYCERIDES, LIPOPROTEIN CHOLESTEROL, AND BLOOD-PRESSURE IN HEALTHY-MEN
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DOI：
10.1161/01.atv.12.9.1030
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发表时间：
1992-09-01
期刊：
影响因子：
--
通讯作者：
OLIVER, MF
中科院分区：
文献类型：
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作者：
GODSLAND, IF;CROOK, D;OLIVER, MF
本文对158名19-77岁、体重指数（BMI）19-41 kg的健康男性的血脂、脂蛋白、血压与胰岛素代谢的关系进行了研究。m-2在静脉内葡萄糖耐量试验期间的葡萄糖、胰岛素和C肽浓度的数学建模分析用于测量胰岛素代谢的参数。在单因素分析中，空腹胰岛素和葡萄糖后胰岛素浓度均与空腹血清甘油三酯水平呈显著正相关（r分别为0.33和0.38）和收缩压（r=0.22和0.26）和舒张期（r=0.21和0.24）血压和高密度脂蛋白亚组分2胆固醇（HDL 2; r=-0.21和-0.25）的负相关。在多变量分析中，发现胰岛素和HDL 2胆固醇浓度之间的关联依赖于甘油三酯水平。胰岛素抵抗和基础胰腺胰岛素分泌与血清甘油三酯呈显著正相关，与年龄、BMI和脂肪分布无关。肝脏胰岛素通量与HDL 2胆固醇独立相关。胰岛素相关变量与血压的相关性通常取决于年龄和BMI。这些结果强调了胰岛素敏感性和胰岛素浓度作为甘油三酯代谢决定因素的重要性。它们还表明肝脏胰岛素处理和HDL 2浓度之间的密切关系，其独立于甘油三酯代谢。
Relations between serum lipids, lipoproteins, blood pressure, and insulin metabolism were investigated in 158 healthy men aged 19-77 years and with body mass indexes (BMIs) of 19-41 kg . m-2. Mathematical modeling analysis of glucose, insulin, and C-peptide concentrations during an intravenous glucose tolerance test was used to measure parameters of insulin metabolism. In univariate analysis, both fastin and postglucose insulin concentrations showed significant positive associations with fasting serum triglyceride levels (r=0.33 and 0.38, respectively) and systolic (r=0.22 and 0.26) and diastolic (r=0.21 and 0.24) blood pressure and negative associations with high density lipoprotein subfraction 2 cholesterol (HDL2; r=-0.21 and -0.25). In multivariate analysis, the associations between insulin and HDL2 cholesterol concentrations were found to depend on triglyceride levels. Insulin resistance and basal pancreatic insulin secretion showed significant positive associations with serum triglycerides, which were independent of the effects of age, BMI, and fat distribution. Hepatic insulin throughput was independently associated with HDL2 cholesterol. Associations of insulin-related variables with blood pressure were generally dependent on age and BMI. These results underline the importance of insulin sensitivity and insulin concentrations as determinants of triglyceride metabolism. They also indicate a close relation between hepatic insulin handling and HDL2 Concentration that is independent of triglyceride metabolism.