A single equivalent moving dipole model: An efficient approach for localizing sites of origin of ventricular electrical activation
A single equivalent moving dipole model: An efficient approach for localizing sites of origin of ventricular electrical activation
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DOI：
10.1114/1.1567281
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发表时间：
2003-05-01
影响因子：
3.8
通讯作者：
Cohen, RJ
中科院分区：
文献类型：
--
作者：
Armoundas, AA;Feldman, AB;Cohen, RJ
我们提出了一种新的方法，指导导管消融术，以消除网站的起源心律失常。该方法对心脏电活动和从具有单个等效移动偶极子（SEMD）的消融导管头端输送的电流脉冲进行建模。通过对体表电位的分析，得到了表面场分布参数。在本文中，我们研究了这种方法的可行性，通过评估我们开发的一个逆算法的性能本地化的表面电位的SEMD。在计算机模拟中，实际的测量噪声水平导致SEMD位置的不确定性接近0.005 cm。偶极方向随机化有助于增加不确定性（0.04厘米）的SEMD位置只有当边界效应。在心室起搏猪研究中，我们发现SEMD模型准确地解释了心电图波形，并且测量噪声导致起搏尖峰后15 ms时SEMD中约0.04 cm的不确定性。我们还发现，我们开发的用于识别SEMD参数的算法产生了两个空间分离的起搏部位的位置，这些起搏部位保持其方向并且非常接近其物理分离。这些结果表明，SEMD方法可能用于指导射频消融手术。(C)2003生物医学工程学会。
We propose a new method for guiding catheter ablation procedures to abolish sites of origin of arrhythmias. This method models both cardiac electrical activity and current pulses delivered from the tip of the ablation catheter with a single equivalent moving dipole (SEMD). The SEMD parameters are obtained from analysis of body surface potentials. In this paper we examine the feasibility of this method by evaluating the performance of an inverse algorithm we developed to localize the SEMD from the surface potentials. In computer simulations realistic levels of measurement noise led to uncertainties in SEMD location similar to0.005 cm. Dipole orientation randomization contributed to increased uncertainty (0.04 cm) in SEMD location only when boundary effects were included. In ventricular pacing swine studies, we found that the SEMD model accurately accounted for electrocardiographic wave forms and that measurement noise led to an uncertainty of approximately 0.04 cm in the SEMD at 15 ms after the pacing spike. We have also found that the algorithm we developed to identify the SEMD parameters yielded positions for two spatially separated pacing sites that maintained their direction and were very close to their physical separation. These results suggest that the SEMD method may potentially be used to guide radio-frequency ablation procedures. (C) 2003 Biomedical Engineering Society.