Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities.
Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities.
复制标题
针对 B 细胞淋巴瘤的肿瘤微环境：挑战和机遇。
DOI：
10.1186/s13045-021-01134-x
复制
发表时间：
2021-08-17
影响因子：
28.5
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Liu Y;Zhou X;Wang X
B细胞淋巴瘤是一组具有高度临床异质性和生物学异质性的血液系统恶性肿瘤。B细胞淋巴瘤的发病机制涉及肿瘤细胞与肿瘤微环境（TME）之间的复杂相互作用，TME由基质细胞和细胞外基质组成。尽管TME的作用尚未完全阐明，但越来越多的证据表明TME与B细胞淋巴瘤的发生、侵袭和转移密切相关。TME的探索为癌症治疗提供了独特的见解。在此，我们总结了TME在B细胞淋巴瘤中的最新进展，并讨论了其在肿瘤进展和免疫逃逸中的作用。此外，突出了靶向TME在B细胞淋巴瘤中的潜在临床价值，这有望为新的治疗策略铺平道路。
B-cell lymphoma is a group of hematological malignancies with high clinical and biological heterogeneity. The pathogenesis of B-cell lymphoma involves a complex interaction between tumor cells and the tumor microenvironment (TME), which is composed of stromal cells and extracellular matrix. Although the roles of the TME have not been fully elucidated, accumulating evidence implies that TME is closely relevant to the origination, invasion and metastasis of B-cell lymphoma. Explorations of the TME provide distinctive insights for cancer therapy. Here, we epitomize the recent advances of TME in B-cell lymphoma and discuss its function in tumor progression and immune escape. In addition, the potential clinical value of targeting TME in B-cell lymphoma is highlighted, which is expected to pave the way for novel therapeutic strategies.