Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico
Clinical characteristics and risk factors for mortality of patients with COVID-19 in a large data set from Mexico
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DOI：
10.1016/j.annepidem.2020.08.005
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发表时间：
2020-12-01
影响因子：
5.6
通讯作者：
Parra-Bracamonte, Francisco E.
中科院分区：
文献类型：
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作者：
Manuel Parra-Bracamonte, Gaspar;Lopez-Villalobos, Nicolas;Parra-Bracamonte, Francisco E.
目的：本研究旨在评估2019年冠状病毒病患者的临床特征和死亡风险因素方法：采用多变量logistic回归模型和Kaplan-Meier生存曲线拟合研究墨西哥COVID-19患者特征和合并症的死亡几率。结果：年龄、性别和最常见的合并症糖尿病、肥胖和高血压与COVID-19死亡风险显著相关（P < .0001）。吸烟习惯未被确定为死亡的危险因素。不常见的合并症如慢性阻塞性肺疾病、慢性肾脏疾病和免疫抑制患者也显示出显著的死亡风险（P <0.0001）。住院患者和肺炎患者有严重的死亡风险（P < .0001），更多地关注特定的条件可能会被认为是在临床admission.Conclusions：一个更脆弱的阳性患者是由男性患者，年龄大于41岁，这增加了他们的风险，更普遍的合并症，如糖尿病，高血压和肥胖。一些影响的结果进行了讨论。(C)2020爱思唯尔公司All rights reserved.
Purpose: The purpose of this study was to assess clinical characteristics and risk factors for mortality of patients with coronavirus disease 2019 (COVID-19) from Mexico, given that it currently is in active community transmission.Methods: Multivariate logistic regression model and Kaplan-Meier survival curves were fitted to study odds of death of characteristics and comorbidities in patients with COVID-19 in Mexico.Results: Age, sex, and the most frequent comorbidities diabetes, obesity, and hypertension were significantly associated to the risk of death by COVID-19 (P < .0001). Smoking habit was not identified as a risk factor for death. Less-frequent comorbidities such as chronic obstructive pulmonary disease, chronic kidney disease, and patients with immunosuppressed conditions also showed a significant risk for death (P < .0001). Hospitalized patients and those with pneumonia had serious risks for mortality (P < .0001), and more attention to specific conditions might be considered during clinical admission.Conclusions: A more vulnerable positive patient is depicted by a male patient, older than 41 years, which increases their risk with more prevalent comorbidities such as diabetes, hypertension, and obesity. Some implications on outcomes are discussed. (C) 2020 Elsevier Inc. All rights reserved.