Polyketides and Terpenoids with Potent Antibacterial Activities from the Artemisia argyi‐Derived Fungus Trichoderma koningiopsis QA‐3
Polyketides and Terpenoids with Potent Antibacterial Activities from the Artemisia argyi‐Derived Fungus Trichoderma koningiopsis QA‐3
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DOI：
10.1002/cbdv.202000566
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发表时间：
2020-09
影响因子：
2.9
通讯作者：
Xiao-Shan Shi;L. Meng;Xin Li;Dun-jia Wang;Xing-Wang Zhou;Feng-Yu Du;Bin‐Gui Wang;Xiao‐Ming Li
中科院分区：
文献类型：
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作者：
Xiao-Shan Shi;L. Meng;Xin Li;Dun-jia Wang;Xing-Wang Zhou;Feng-Yu Du;Bin‐Gui Wang;Xiao‐Ming Li
艾蒿真菌Trichoderma koningiopsis QA-3的AcOEt提取物对病原菌具有较强的抑制活性。提取物的分级导致分离出三种新的聚酮化合物（1-3）和两种新的萜类化合物（4和5），以及三种已知的代谢物（6-8）。通过NMR光谱、ECD、HR-ESI-MS或HR-EI-MS、旋光度和X射线晶体学数据以及与文献报道的比较分析了它们的化学结构。在抗菌试验中，3-羟基哈茨烷二酮（4）对人类病原体大肠杆菌显示出有效活性，MIC值为0.5 μg/mL，而6-（3-羟基戊-1-烯-1-基）-2H-吡喃-2-酮对海洋来源的水生病原体藤黄微球菌显示出较强活性，MIC值为1.0 μg/mL。
The AcOEt extract of Artemisia argyi‐derived fungus Trichoderma koningiopsis QA‐3 showed potent inhibitory activity against pathogenic bacteria. Fractionation of the extract resulted in the isolation of three new polyketides (1–3) and two new terpenoids (4 and 5), together with three known metabolites (6–8). Their chemical structures were analyzed by NMR spectra, ECD, HR‐ESI‐MS or HR‐EI‐MS, optical rotation, and X‐ray crystallographic data, as well as by comparison with literature reports. In the antibacterial assays, 3‐hydroxyharziandione (4) showed potent activity against human pathogen Escherichia coli with an MIC value of 0.5 μg/mL, while 6‐(3‐hydroxypent‐1‐en‐1‐yl)‐2H‐pyran‐2‐one exhibited strong activity against marine‐derived aquatic pathogen Micrococcus luteus with an MIC value of 1.0 μg/mL.