Seasonal increase in human IgE and IgG4 antisaliva antibodies to Aedes mosquito bites
Seasonal increase in human IgE and IgG4 antisaliva antibodies to Aedes mosquito bites
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DOI：
10.1159/000237696
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发表时间：
1997-12-01
影响因子：
2.8
通讯作者：
Reunala, T
中科院分区：
文献类型：
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作者：
Palosuo, K;BrummerKorvenkonito, H;Reunala, T
背景：对蚊虫叮咬敏感的个体经常有针对伊蚊唾液蛋白的循环IgE和IgG4抗体。方法：在本研究中，我们检测了生活在芬兰拉普兰的14名个体在一个蚊虫季节期间的抗体反应。用普通伊蚊唾液进行免疫印迹分析，并对22千道尔顿和36千道尔顿的抗唾液抗体条带进行分析。结果：季前血清显示12名个体有针对主要唾液抗原的IgE抗体，所有14名个体都有IgG4抗体，12名个体有IgG1抗体，除1名个体外，所有个体的季后血清均有这些抗体。季后血清显示IgE强度显著更高（p
Background: Mosquito bite-sensitive subjects frequently have circulating IgE and IgG4 antibodies to Aedes mosquito saliva proteins. Methods: In the present study we examined the antibody response during a mosquito season in 14 subjects living in Finnish Lapland. Immunoblotting was performed with Aedes communis saliva and the 22- and 36-kD antisaliva antibody bands were analyzed. Results: The preseason sera showed IgE antibodies to the main saliva antigens in 12, IgG4 antibodies in all 14 and IgG1 antibodies in 12 subjects, and the postseason sera in all but 1 subject. The postseason sera showed significantly more intense IgE (p