Differential effects of fornix and caudate nucleus lesions on two radial maze tasks: evidence for multiple memory systems
Differential effects of fornix and caudate nucleus lesions on two radial maze tasks: evidence for multiple memory systems
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DOI：
10.1523/jneurosci.09-05-01465.1989
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发表时间：
1989-05
期刊：
影响因子：
--
通讯作者：
M. Packard;R. Hirsh;N. White
中科院分区：
文献类型：
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作者：
M. Packard;R. Hirsh;N. White
本实验旨在检验哺乳动物大脑包含解剖学上不同的记忆系统的假设。术后对尾状核或穹窿海马伞双侧病变的大鼠和对照组进行2个版本中的1个版本的放射状迷宫任务测试。在一个标准的胜利转移版本中，迷宫的8个臂中的每一个都被诱饵一次，并且记录每次试验的前8个选择中的错误（重访）的数量。穹窿海马伞大鼠的选择准确性受损，而尾状核动物相对于对照组未受损。在新开发的赢得停留版本的径向迷宫上测试具有类似病变的不同组大鼠，其中4个随机选择的诱饵臂的位置通过每个臂入口处的灯发出信号，并且要求大鼠重新访问先前在试验中获得强化的臂。穹窿海马伞病变的大鼠上级对照组的选择准确性的胜利停留径向迷宫任务，而尾状动物受损相对于对照组。结果表明，海马和尾状核的记忆功能的双重分离。本文还讨论了哺乳动物大脑中存在两种记忆系统的一些意义。
The present experiments were designed to examine the hypothesis that the mammalian brain contains anatomically distinct memory systems. Rats with bilateral lesions of caudate nucleus or fimbria-fornix and a control group were tested postoperatively on 1 of 2 versions of the radial maze task. In a standard win-shift version, each of the 8 arms of the maze was baited once, and the number of errors (revisits) in the first 8 choices of each trial was recorded. Fimbria-fornix rats were impaired in choice accuracy, while caudate animals were unimpaired relative to controls. Different groups of rats with similar lesions were tested on a newly developed win-stay version of the radial maze, in which the location of 4 randomly selected baited arms was signaled by a light at the entrance to each arm, and which required rats to revisit arms in which reinforcement had been previously acquired within a trial. Rats with fimbria-fornix lesions were superior to controls in choice accuracy on the win-stay radial maze task, while caudate animals were impaired relative to controls. The results demonstrate a double dissociation of the mnemonic functions of the hippocampus and caudate nucleus. Some implications of the presence of 2 memory systems in the mammalian brain are discussed.