Abnormal white matter microstructures in Parkinson's disease and comorbid depression: A whole-brain diffusion tensor imaging study
Abnormal white matter microstructures in Parkinson's disease and comorbid depression: A whole-brain diffusion tensor imaging study
复制标题
帕金森病和共病抑郁症的白质微结构异常：全脑弥散张量成像研究
DOI：
10.1016/j.neulet.2020.135238
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发表时间：
2020-09-14
影响因子：
2.5
通讯作者：
Qian, Long
中科院分区：
文献类型：
--
作者：
Li, Zonghong;Liu, Weiguo;Qian, Long
目的：抑郁症状是帕金森病（PD）最常见的非运动症状，但PD抑郁的神经基础尚不清楚。本研究的目的是表征可能与抑郁症相关的白色物质的微结构差异与PD患者和健康对照组（HC）相比，PD患者和共病抑郁症without depression.Methods：我们采用扩散张量成像（DTI）分析白色物质的完整性抑郁症患者（n = 30），非抑郁症PD患者（n = 43），HC（n = 91）。估计五个MRI衍生指数：各向异性分数（FA）、平均扩散率（MD）、轴向扩散率（AD）、径向扩散率（RD）和白色物质体积（WMV）。与HC和非抑郁PD患者相比，抑郁PD患者在胼胝体、右侧前放射冠和左侧扣带回海马部分的AD值显著增加，结论：我们的研究结果表明，抑郁症PD患者额叶和边缘白色物质的完整性受损。这些发现可用于更好地了解PD抑郁症的潜在机制。
Objective: Depressive symptoms are the most common non-motor symptom accompanying Parkinson's disease (PD); however, the neural basis of depression in PD remains unclear. The aim of this study was to characterize possible depression-related white matter microstructural differences in patients with PD and comorbid depression compared with PD patients and healthy controls (HC) without depression.Methods: We used diffusion tensor imaging (DTI) to analyze white matter integrity in depressed PD patients (n = 30), non-depressed PD patients (n = 43), and HC (n = 91). Five MRI-derived indices were estimated: fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), and white matter volume (WMV).Results: Compared with HC and non-depressed PD, depressed PD patients showed significantly increased AD values in the body of corpus callosum, right anterior corona radiate, and left hippocampal part of the cingulum, as well as increased MD values in the left hippocampal part of the cingulum.Conclusions: Our results show that frontal and limbic white matter integrity is impaired in depressed PD patients. These findings can be used to better understand potential mechanisms of depression in PD.