Prognostic value of pretreatment and recovery duration of cranial nerve palsy in nasopharyngeal carcinoma.
Prognostic value of pretreatment and recovery duration of cranial nerve palsy in nasopharyngeal carcinoma.
复制标题
鼻咽癌颅神经麻痹预处理和恢复时间的预后价值
DOI：
10.1186/1748-717x-7-149
复制
发表时间：
2012-09-07
期刊：
影响因子：
--
通讯作者：
Mai HQ
中科院分区：
文献类型：
--
作者：
Mo HY;Sun R;Sun J;Zhang Q;Huang WJ;Li YX;Yang J;Mai HQ
BackgroundThe purpose of this study was to evaluate the prognostic value of cranial nerve (CN) palsy in nasopharyngeal carcinoma (NPC) patients.MethodsA retrospective analysis was performed on CN involvement using medical records of 178 consecutive patients with histologically diagnosed, non-disseminated NPC.ResultsIn 178 NPC patients with CN palsy, the 5-year survival rates were as follows: overall survival (OS), 61.0%; disease-specific survival (DSS), 69.6%; local relapse-free survival (LRFS), 75.2%; distant metastasis-free survival (DMFS), 73.4%; and disease-free survival (DFS), 55.3%. Significant differences were observed in the 5-year OS rates between patients with single and multiple CN palsy (69.8% vs. 54.3%; P = 0.033) and the OS rates between patients with different pretreatment durations (68.7% vs. 43.3%, P = 0.007). However, no significant differences were observed in OS, DSS, LRFS and DFS rates between patients with upper and lower CN palsy (P = 0.581, P = 0.792, P = 0.729 and P = 0.212, respectively). The results showed that recovery duration was an independent prognostic factor for OS (HR = 2.485; P < 0.001), DSS (HR = 2.065; P = 0.016), LRFS (HR = 3.051; P = 0.001) and DFS (HR = 2.440; P < 0.001).ConclusionsRecovery duration is an independent prognostic factor for NPC patients with CN palsy and is related to recurrence, which leads to poor survival. Recovery duration requires close surveillance and different treatment regimens.
