Characterization of β-D-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus
Characterization of β-D-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus
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DOI：
10.1128/aac.02395-16
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发表时间：
2017-04-01
影响因子：
4.9
通讯作者：
Schinazi, Raymond F.
中科院分区：
文献类型：
--
作者：
Ehteshami, Maryam;Tao, Sijia;Schinazi, Raymond F.
基孔肯雅病毒（CHIKV）是对人类健康重新出现的全球性威胁。最近在亚洲、欧洲、非洲和加勒比地区爆发的疫情重新引起了科学界对这种蚊子传播的甲病毒的兴趣。目前没有针对CHIKV的疫苗，治疗仅限于非特异性抗病毒药物，效果不理想。在这里，我们已经确定了β - d - n（4-）羟基胞苷（NHC）作为一种新的CHIKV抑制剂。NHC作为一种嘧啶核糖核苷，在细胞培养中选择性地抑制CHIKV复制。
Chikungunya virus (CHIKV) represents a reemerging global threat to human health. Recent outbreaks across Asia, Europe, Africa, and the Caribbean have prompted renewed scientific interest in this mosquito-borne alphavirus. There are currently no vaccines against CHIKV, and treatment has been limited to nonspecific antiviral agents, with suboptimal outcomes. Herein, we have identified beta-D-N(4-)hydroxycytidine (NHC) as a novel inhibitor of CHIKV. NHC behaves as a pyrimidine ribonucleoside and selectively inhibits CHIKV replication in cell culture.