Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity
Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity
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DOI：
10.1038/ni1134
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发表时间：
2004-12-01
影响因子：
30.5
通讯作者：
Amigorena, S
中科院分区：
文献类型：
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作者：
Hugues, S;Fetler, L;Amigorena, S
免疫和外周免疫耐受的诱导需要携带抗原的树突状细胞(DC)和同源T细胞之间的接触。利用实时双光子显微镜，我们分析了CD8(+)T细胞在抗原特异性免疫或耐受诱导过程中的动态变化。免疫诱导后15~20h，T细胞停止运动，并与DC建立长时间的相互作用。在耐受性条件下，尽管初始T细胞有效地激活和增殖，但初始T细胞仍然活跃，并与多个DC建立了一系列短暂的接触。因此，稳定的DC-T细胞相互作用发生在启动的诱导过程中，而短暂的接触可能有助于T细胞耐受的诱导。
Induction of immunity and peripheral tolerance requires contacts between antigen-bearing dendritic cells (DCs) and cognate T cells. Using real-time two-photon microscopy, we have analyzed the dynamics of CD8(+) T cells in lymph nodes during the induction of antigen-specific immunity or tolerance. At 15-20 h after the induction of immunity, T cells stopped moving and established prolonged interactions with DCs. In tolerogenic conditions, despite effective initial T cell activation and proliferation, naive T cells remained motile and established serial brief contacts with multiple DCs. Thus, stable DC-T cell interactions occur during the induction of priming, whereas brief contacts may contribute to the induction of T cell tolerance.