Odor maps in the mammalian olfactory bulb: domain organization and odorant structural features
Odor maps in the mammalian olfactory bulb: domain organization and odorant structural features
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DOI：
10.1038/79857
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发表时间：
2000-10-01
影响因子：
25
通讯作者：
Mori, K
中科院分区：
文献类型：
--
作者：
Uchida, N;Takahashi, YK;Mori, K
心理物理学研究表明，气味的结构特征对其感知的气味有不同的影响。在嗅球(OB)中，气味是由激活的肾小球组合表示的。在这里，我们使用内部信号的光学成像来检查这些结构特征是如何在大鼠OB的感觉图中空间表示的。我们发现，背侧OB含有两个固定的结构域；每个结构域中的组成小球可以被具有特定功能基团的气味激活。在每个结构域内，碳链长度和分支等其他结构特征由模式上的局部差异表示。这些结果表明，结构特征可以分为两类，主要特征(功能群)表征每个领域，次要特征由每个领域中的局部位置表示。不同结构特征的这种层次化表征与心理物理结构-气味关系有很好的相关性。
Psychophysical studies indicate that structural features of odorants differentially influence their perceived odor. In the olfactory bulb (OB), odorants are represented by ensembles of activated glomeruli. Here we used optical imaging of intrinsic signals to examine how these structural features are represented spatially in the sensory map of the rat OB. We found that the dorsal OB contained two topographically fixed domains; constituent glomeruli in each domain could be activated by odorants with particular functional groups. Within each domain, other structural features such as carbon chain length and branching were represented by local differences in patterns. These results suggest that structural features are categorized into two classes, primary features (functional groups) that characterize each domain, and secondary features that are represented by local positions within each domain. Such hierarchical representations of different structural features correlate well with psychophysical structure-odor relationships.