Direct Asymmetric Dearomatization of 2-Naphthols by Scandium-Catalyzed Electrophilic Amination
Direct Asymmetric Dearomatization of 2-Naphthols by Scandium-Catalyzed Electrophilic Amination
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钪催化亲电胺化直接不对称脱芳构化 2-萘酚
DOI：
10.1002/anie.201409565
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发表时间：
2015-02-16
影响因子：
16.6
通讯作者：
Luan, Xinjun
中科院分区：
文献类型：
--
作者：
Nan, Jiang;Liu, Jingjing;Luan, Xinjun
在手性SC-III/PYBOX络合物催化下，亲电偶氮二甲酸酯催化1-取代2-萘酚的不对称氨基脱芳构化反应。这种分子间反应代表了一种迄今未知的通过酚类化合物直接脱芳构化生成手性含氮季碳立体中心的对映选择性氰键形成过程。
Catalytic asymmetric aminative dearomatization of 1-substituted 2-naphthols was successfully implemented with electrophilic azodicarboxylates under the catalysis of chiral Sc-III/pybox complexes. This intermolecular reaction represents a hitherto unknown enantioselective CN bond-forming process through direct dearomatization of phenolic compounds to generate chiral nitrogen-containing quaternary carbon stereocenters.