World Health Organization Ranking of Antimicrobials According to Their Importance in Human Medicine: A Critical Step for Developing Risk Management Strategies for the Use of Antimicrobials in Food Production Animals
World Health Organization Ranking of Antimicrobials According to Their Importance in Human Medicine: A Critical Step for Developing Risk Management Strategies for the Use of Antimicrobials in Food Production Animals
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DOI：
10.1086/599374
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发表时间：
2009-07-01
影响因子：
11.8
通讯作者：
Aarestrup, Frank M.
中科院分区：
文献类型：
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作者：
Collignon, Peter;Powers, John H.;Aarestrup, Frank M.
在食用动物中使用抗菌剂为可通过食物供应传播给人类的抗微生物细菌创造了一个重要来源。改善对食用动物使用抗菌素的管理，特别是减少对人类医学“至关重要”的抗菌素的使用，是朝着保持抗菌素对人类的益处迈出的重要一步。世界卫生组织根据抗菌素在人类医学中的相对重要性制定并应用了对抗菌素进行排名的标准。临床医生、监管机构、政策制定者和其他利益攸关方在制定食品生产动物使用抗微生物药物的风险管理战略时，可以利用这一排名。该排名使利益攸关方能够将风险管理工作重点放在对人类医学最重要、因此需要最迫切解决的食用动物中使用的药物上，例如氟喹诺酮类药物、大环内酯类药物以及第三代和第四代头孢菌素。
The use of antimicrobials in food animals creates an important source of antimicrobial-resistant bacteria that can spread to humans through the food supply. Improved management of the use of antimicrobials in food animals, particularly reducing the usage of those that are "critically important" for human medicine, is an important step toward preserving the benefits of antimicrobials for people. The World Health Organization has developed and applied criteria to rank antimicrobials according to their relative importance in human medicine. Clinicians, regulatory agencies, policy makers, and other stakeholders can use this ranking when developing risk management strategies for the use of antimicrobials in food production animals. The ranking allows stakeholders to focus risk management efforts on drugs used in food animals that are the most important to human medicine and, thus, need to be addressed most urgently, such as fluoroquinolones, macrolides, and third-and fourth-generation cephalosporins.