Influence of anesthesia on bladder hyperactivity induced by middle cerebral artery occlusion in the rat.
Influence of anesthesia on bladder hyperactivity induced by middle cerebral artery occlusion in the rat.
复制标题
麻醉对大脑中动脉闭塞大鼠膀胱过度活动的影响。
DOI：
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发表时间：
1997
影响因子：
--
通讯作者：
W. D. de Groat
中科院分区：
文献类型：
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作者：
O. Yokoyama;M. Yoshiyama;M. Namiki;W. D. de Groat
在雌性大鼠中，观察麻醉或N-甲基-D-天冬氨酸（NMDA）受体拮抗剂（MK-801）对单侧大脑中动脉（MCA）闭塞引起的膀胱过度活动的影响。在梗塞前，在两组大鼠中监测对照膀胱收缩：1）清醒和2）乌拉坦麻醉。清醒大鼠用氟烷麻醉，两组均行MCA阻断。从氟烷中恢复后，清醒大鼠的膀胱容量在MCA闭塞后0.5-4.5 h显著降低（60.8 +/- 1.3%），但在麻醉大鼠中没有变化。MK-801（0.1 mg/kg i.v.）在MCA阻塞前给药阻断MCA阻塞后1.5-4.5小时清醒大鼠膀胱容量的减少。在清醒或麻醉大鼠中，假手术均未改变膀胱容量。氟烷麻醉恢复后给予乌拉坦可增加MCA闭塞清醒大鼠的膀胱容量，但在假手术清醒大鼠中不增加。氟烷麻醉或MK-801给药大鼠的脑区无显著差异。这些结果表明，脑梗死诱导清醒大鼠的膀胱过度活动，氨基甲酸乙酯或MK-801抑制这种过度活动的发展，最有可能是通过阻断大脑中的多巴胺能传递。
The effect of anesthesia or an N-methyl-D-aspartate (NMDA) glutamatergic antagonist (MK-801) on bladder hyperactivity induced by unilateral middle cerebral artery (MCA) occlusion was examined in female rats. Before infarction, control bladder contractions were monitored in two groups of rats: 1) awake and 2) urethan anesthetized. The awake rats were then anesthetized with halothane, and MCA occlusion was performed in both groups. After recovery from halothane, bladder capacity in awake rats was significantly reduced (60.8 +/- 1.3%) 0.5-4.5 h after MCA occlusion but not changed in urethan-anesthetized rats. MK-801 (0.1 mg/kg i.v.) administered before MCA occlusion blocked the reduction in bladder capacity in awake rats 1.5-4.5 h after MCA occlusion. Bladder capacity was not changed by sham operation in either the awake or urethan-anesthetized rats. Urethan administered after recovery from halothane anesthesia increased bladder capacity in MCA-occluded awake rats but not in sham-operated awake rats. Infarct areas in halothane, urethan-anesthetized, or MK-801-treated rats were not significantly different. These results indicate that cerebral infarction induces bladder hyperactivity in awake rats and that urethan or MK-801 inhibits the development of this hyperactivity, most likely by blocking glutamatergic transmission in the brain.
影响因子：
5
作者：
M. Yoshiyama;J. Roppolo;W. C. Groat
通讯作者：
M. Yoshiyama;J. Roppolo;W. C. Groat