Navigating in Deep Waters: How Tissue Damage and Inflammation Shape Effector and Memory CD8+ T Cell Responses.
Navigating in Deep Waters: How Tissue Damage and Inflammation Shape Effector and Memory CD8+ T Cell Responses.
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DOI：
10.4049/immunohorizons.2000102
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发表时间：
2021-05-25
期刊：
影响因子：
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通讯作者：
Borges da Silva, Henrique
中科院分区：
文献类型：
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作者：
Borges da Silva, Henrique
记忆性CD 8 + T细胞促进对病毒或癌症的保护性免疫。我们的领域已经做了一个了不起的工作，确定如何CD 8 + T细胞的记忆形式，以响应银。然而，许多研究集中在炎症随时间推移而消退的系统上。这些情况虽然相关，但并不涵盖CD 8 + T细胞记忆相关的所有情况。越来越清楚的是，具有记忆表型的CD 8 + T细胞是响应于广泛或长期组织炎症的感染而形成的，例如流感、疱疹和最近的COVID-19。在这些情况下，炎症介质会影响记忆性CD 8 + T细胞的形成，特别是在病原体建立的组织中。尽管最近有重要的发现，炎症如何塑造CD 8 + T细胞记忆的许多悬而未决的问题仍然没有答案。我们将讨论，在这篇综述中，什么是已知的和下一步了解炎症如何影响CD 8 + T细胞的记忆。
Memory CD8+ T cells promote protective immunity against viruses or cancer. Our field has done a terrific job identifying how CD8+ T cell memory forms in response to Ag. However, many studies focused on systems in which inflammation recedes over time. These situations, while relevant, do not cover all situations in which CD8+ T cell memory is relevant. It is increasingly clear that CD8+ T cells with a memory phenotype form in response to infections with extensive or prolonged tissue inflammation, for example, influenza, herpes, and more recently, COVID-19. In these circumstances, inflammatory mediators expectedly affect forming memory CD8+ T cells, especially in tissues in which pathogens establish. Notwithstanding recent important discoveries, many outstanding questions on how inflammation shapes CD8+ T cell memory remain unanswered. We will discuss, in this review, what is already known and the next steps to understand how inflammation influences CD8+ T cell memory.