Magnetic nanoparticle transport within flowing blood and into surrounding tissue.
Magnetic nanoparticle transport within flowing blood and into surrounding tissue.
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DOI：
10.2217/nnm.10.104
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发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
Shapiro B
中科院分区：
文献类型：
--
作者：
Nacev A;Beni C;Bruno O;Shapiro B
磁性药物递送是指将治疗性磁性纳米颗粒物理限制在疾病、肿瘤、感染和血凝块区域。预测体内磁聚焦的有效性对于磁性给药系统的设计和使用至关重要。然而，目前简单的粗略估计已被证明不足以完成这项任务。在这篇文章中，我们分析了纳米颗粒在体内任何深度的单个血管（克拉夫组织圆柱体）内和周围的分布，以及任何生理相关的血流速度、扩散和外渗特性，以及任何施加在颗粒上的磁力。对于任何这样的血管，我们的分析预测了三种不同类型的粒子行为（速度主导，磁性主导或边界层形成）中的一种，这可以通过查找我们定义的三个非三维数字的值来唯一确定。我们将我们的预测与先前发表的体外和体内磁聚焦研究进行比较。我们不仅发现了我们的预测和先前的观察之间的一致性，而且我们还能够定量地解释以前不理解的行为。
Magnetic drug delivery refers to the physical confinement of therapeutic magnetic nanoparticles to regions of disease, tumors, infections and blood clots. Predicting the effectiveness of magnetic focusing in vivo is critical for the design and use of magnetic drug delivery systems. However, current simple back-of-the-envelope estimates have proven insufficient for this task. In this article, we present an analysis of nanoparticle distribution, in and around a single blood vessel (a Krogh tissue cylinder), located at any depth in the body, with any physiologically relevant blood flow velocity, diffusion and extravasation properties, and with any applied magnetic force on the particles. For any such blood vessel our analysis predicts one of three distinct types of particle behavior (velocity dominated, magnetic dominated or boundary-layer formation), which can be uniquely determined by looking up the values of three nondimensional numbers we define. We compare our predictions to previously published magnetic-focusing in vitro and in vivo studies. Not only do we find agreement between our predictions and prior observations, but we are also able to quantitatively explain behavior that was not understood previously.