Genetics of asthma and COPD. Similar results for different phenotypes.
Genetics of asthma and COPD. Similar results for different phenotypes.
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DOI：
10.1378/chest.126.2_suppl_1.105s
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发表时间：
2004-08-01
期刊：
影响因子：
9.6
通讯作者：
Lange, Leslie
中科院分区：
文献类型：
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作者：
Meyers, Deborah A;Larj, Michael J;Lange, Leslie
哮喘和慢性阻塞性肺疾病是常见的呼吸系统疾病，由遗传易感性和环境因素相互作用引起。环境影响在这两种疾病中都很重要，尽管遗传易感性存在差异，但也有相似之处。讨论了哮喘和慢性阻塞性肺病患者感兴趣的三个例子。首先是家庭研究的结果，这些研究表明哮喘相关表型和COPD相关表型的易感基因位于同一染色体区域。第二，与COPD患者的个人吸烟相比，哮喘患者的被动吸烟与基因-环境相互作用的证据将被涵盖。第三个是一个候选基因(白介素13)的例子，在哮喘和COPD中观察到了类似的结果。
Asthma and COPD are common respiratory diseases that are caused by the interaction of genetic susceptibility with environmental factors. Environmental influences are important in both diseases, and although there are differences in genetic susceptibilities, there are also similarities. Three examples of interest for both asthma and COPD patients are discussed. The first is the results of family studies, which have shown evidence for susceptibility loci for both asthma-related and COPD-related phenotypes in the same chromosomal region. Second, evidence for a gene-environment interaction with passive smoking for asthma patients compared with individual smoking for COPD patients will be covered. The third is an example of one candidate gene (interleukin-13), in which similar results have been observed for both asthma and COPD.