Association of higher levels of ambient criteria pollutants with impaired cardiac autonomic control: A population-based study
Association of higher levels of ambient criteria pollutants with impaired cardiac autonomic control: A population-based study
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DOI：
10.1093/aje/kwh109
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发表时间：
2004-04-15
影响因子：
5
通讯作者：
Lin, HM
中科院分区：
文献类型：
--
作者：
Liao, DP;Duan, YK;Lin, HM
空气污染与心血管疾病(CVD)死亡率增加之间的关联已有报道，但其潜在机制尚不清楚。作者研究了环境污染物(空气动力学直径小于10微米的颗粒物(PM10)、臭氧、一氧化碳、二氧化氮和二氧化硫)和心脏自主神经控制之间的短期关系，这些数据来自基于人群的动脉粥样硬化风险社区研究的第四次队列检查(1996-1998)。对于每个参与者，作者计算了PM10和气体污染物暴露量为24小时平均值，臭氧暴露量为随机分配的考试日期前1天的8小时平均值。他们计算了5分钟的心率变异性指数，并使用了高频(0.15-0.40赫兹)和低频(0.04-0.15赫兹)功率、正常R-R间期的标准差和平均心率的对数转换数据。线性回归被用来调整心血管疾病危险因素和人口统计学、社会经济和气象变量。对于对数变换的高频功率、正常R-R间期的标准差和心率，PM10增加一个标准差(11.5mug/m(3))的回归系数分别为-0.06ms(2)(标准差(SE)，0.018)、-1.03ms(SE，0.31)和0.32次/分钟(SE，0.158)。对气态污染物也发现了类似的结果。这些横断面研究结果表明，较高的环境污染物浓度与较低的心脏自主神经控制有关，特别是在已有心血管疾病的人中，并强调了空气污染与心血管疾病相关的可能机制。
An association between air pollution and increased cardiovascular disease (CVD) mortality has been reported, but underlying mechanisms are unknown. The authors examined short-term associations between ambient pollutants (particulate matter less than 10 mum in aerodynamic diameter (PM10), ozone, carbon monoxide, nitrogen dioxide, and sulfur dioxide) and cardiac autonomic control using data from the fourth cohort examination (1996-1998) of the population-based Atherosclerosis Risk in Communities Study. For each participant, the authors calculated PM10 and gaseous pollutant exposures as 24-hour averages and ozone exposure as an 8-hour average 1 day prior to the randomly allocated examination date. They calculated 5-minute heart rate variability indices and used logarithmically transformed data on high-frequency (0.15-0.40 Hz) and low-frequency (0.04-0.15 Hz) power, standard deviation of normal R-R intervals, and mean heart rate. Linear regression was used to adjust for CVD risk factors and demographic, socioeconomic, and meteorologic variables. Regression coefficients for a one-standard-deviation increase in PM10 (11.5 mug/m(3)) were -0.06 ms(2) (standard error (SE), 0.018), -1.03 ms (SE, 0.31), and 0.32 beats/minute (SE, 0.158) for log-transformed high-frequency power, standard deviation of normal R-R intervals, and heart rate, respectively. Similar results were found for gaseous pollutants. These cross-sectional findings suggest that higher ambient pollutant concentrations are associated with lower cardiac autonomic control, especially among persons with existing CVD, and highlight a putative mechanism through which air pollution is associated with CVD.