Toward the development of podocyte-specific drugs.
Toward the development of podocyte-specific drugs.
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DOI：
10.1038/ki.2009.559
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发表时间：
2010-04
影响因子：
19.6
通讯作者：
Kistler, Andreas D.
中科院分区：
文献类型：
--
作者：
Reiser, Jochen;Gupta, Vineet;Kistler, Andreas D.
关键词：
最终导致终末期肾衰竭的大多数肾脏疾病起源于肾小球内，并与蛋白尿有关。治疗方案是非特异性的，最多只能部分治愈，因为现有的治疗方法主要不治疗肾小球细胞，而是全身性作用，因此会引起许多副作用。大多数肾小球病直接源于足细胞的损伤，足细胞在肾小球滤过器的维持中起关键作用。因此，这些细胞构成了开发新型肾脏保护药物的明显且有前途的靶点。在过去的十年中，足细胞的结构和功能的理解已经取得了巨大的进步。在肾小球疾病期间改变的许多途径可能是新型小分子和大分子药物以及在肾脏学和其他药物开发领域中已确定的生物制剂的靶向。培养的足细胞为高通量药物筛选试验提供了有价值的模型。此外，足细胞已被证明具有许多特征，使其成为肾保护的特别好的靶细胞。这篇简短的综述讨论了最近一些有希望的数据，这些数据与通过直接靶向足细胞治疗蛋白尿和肾脏疾病的潜在药物治疗有关。
Most kidney diseases that ultimately lead to end-stage renal failure originate within the glomerulus and are associated with proteinuria. Treatment options are unspecific and offer partial cures at best because available therapies do not primarily treat glomerular cells but rather act systemically and thus cause many side effects. Most glomerulopathies directly stem from injury to podocytes, cells that have a key role in the maintenance of the glomerular filter. Thus, these cells constitute an obvious and promising target for the development of novel kidney-protective drugs. During the last decade, enormous advances have been made in the understanding of podocyte structure and function. A number of pathways that are altered during glomerular diseases may be targeted by novel small- and large-molecule drugs as well as biologicals that have been identified in nephrology and other areas of drug development. Cultured podocytes provide a valuable model for high-throughput drug screening assays. Furthermore, podocytes have been shown to possess many features that make them particularly good target cells for renal protection. This mini-review discusses some of the most recent promising data related to potential drug therapy for proteinuria and kidney disease through direct podocyte targeting.
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