P300 amplitude in nonalcoholic adolescent twin pairs who become discordant for alcoholism as adults
P300 amplitude in nonalcoholic adolescent twin pairs who become discordant for alcoholism as adults
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DOI：
10.1111/j.1469-8986.2004.00238.x
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发表时间：
2004-11-01
期刊：
影响因子：
3.7
通讯作者：
McGue, M
中科院分区：
文献类型：
--
作者：
Carlson, SR;Iacono, WG;McGue, M
过去的报告表明，P300波幅降低与酒精中毒的风险有关。我们研究了视觉P300波幅是否可以在记录到P300波幅的未知个体中识别出酒精障碍的基本风险。这些人是双胞胎，双胞胎在17岁时都没有酒精障碍，但当双胞胎中的一个在20岁时患上酒精障碍而另一个没有的时候，家族风险就被确定了。特别令人感兴趣的是未受影响的双胞胎在17岁时记录的P300，当时两个双胞胎都没有酗酒。我们发现，与双胞胎中两个成员都连续无紊乱的双胞胎相比，未受影响的双胞胎的P300降低。因此，在无酒精障碍的个体中，其双胞胎兄弟姐妹随后发展为酒精中毒的人的P300降低，进一步支持P300振幅降低作为酒精中毒家庭风险的内表型指标。
Past reports suggest that reduced P300 amplitude is associated with risk for alcoholism. We examined whether visual P300 amplitude Could identify faimilial risk for alcohol disorders in individuals not known to be at risk at the tin-le P300 was recorded. These individuals were twins from pairs where neither twin had an alcohol disorder at age 17 but familial risk was established at age 20 when one twin developed an alcohol disorder whereas the other did not. Of special interest was the P300 of the unaffected twin recorded at age 17 when both twins were alcoholism free. We found reduced P300 in the unaffected twin compared to pairs where both members were continuously disorder free. Hence, P300 was reduced in alcohol disorder-free individuals whose twin siblings subsequently developed alcoholism, further supporting reduced P300 amplitude as an endophenotype indexing familial risk for alcoholism.