RELATIONSHIP BETWEEN SUSCEPTIBILITY TO APOPTOSIS AND FAS EXPRESSION IN PERIPHERAL-BLOOD T-CELLS FROM UREMIC PATIENTS - A POSSIBLE MECHANISM FOR LYMPHOPENIA IN CHRONIC-RENAL-FAILURE
RELATIONSHIP BETWEEN SUSCEPTIBILITY TO APOPTOSIS AND FAS EXPRESSION IN PERIPHERAL-BLOOD T-CELLS FROM UREMIC PATIENTS - A POSSIBLE MECHANISM FOR LYMPHOPENIA IN CHRONIC-RENAL-FAILURE
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DOI：
10.1006/bbrc.1995.2438
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发表时间：
1995-10-04
影响因子：
3.1
通讯作者：
MAEDA, K
中科院分区：
文献类型：
--
作者：
MATSUMOTO, Y;SHINZATO, T;MAEDA, K
慢性肾功能衰竭(CRF)通常合并淋巴细胞减少，这可能是免疫缺陷的部分原因。我们推测CRF中的淋巴细胞减少可能是体内T细胞的凋亡所致。为了阐明介导细胞凋亡的Fas抗原的参与，我们分析了尿毒症非透析(Non-HD)患者和血液透析(HD)患者外周血T细胞表面Fas的表达。两组尿毒症患者T细胞表达PAS的强度均高于对照T细胞。两组尿毒症患者比较，非HD患者T细胞表面Fas表达强度明显高于HD患者。此外，尿毒症T细胞在体外培养时发生了加速的凋亡，这与Fas的表达有关。我们的结果提示CRF中的T细胞可能通过Fas系统发生凋亡，血液透析治疗可能通过抑制T细胞的凋亡而起到有益的作用。(C)1995年学术出版社。
Chronic renal failure (CRF) is often complicated by lymphopenia, which may be partly responsible for immune deficiency. We hypothesized that lymphopenia in CRF might result from apoptosis of T cells in vivo. To elucidate the involvement of Fas antigen which mediates apoptosis, we analyzed Fas expression on peripheral blood T cells in uremic non-dialyzed (non-HD) patients and hemodialysis (HD) patients. T cells from both uremic groups expressed Pas with higher intensity than control T cells. When two uremic groups were compared, Fas intensity on T cells was significantly higher in non-HD patients than in patients on HD. Moreover, uremic T cells were shown to undergo accelerated apoptosis when cultured in vitro, in correlation with Fas expression. Our results suggest that T cells in CRF may undergo apoptosis by the Fas system and that hemodialysis treatment has beneficial effects in the light of the inhibition of T cell apoptosis. (C) 1995 Academic Press, Inc.