Prenatal alcohol consumption and fetal growth restriction: Potentiation effect by concomitant smoking
Prenatal alcohol consumption and fetal growth restriction: Potentiation effect by concomitant smoking
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DOI：
10.1093/ntr/ntn014
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发表时间：
2009-01-01
影响因子：
4.7
通讯作者：
Salihu, Hamisu M.
中科院分区：
文献类型：
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作者：
Aliyu, Muktar H.;Wilson, Ronee E.;Salihu, Hamisu M.
本研究调查母亲吸烟是否会改变妊娠期饮酒与小于胎龄儿（SGA）分娩风险之间的关系，我们采用了密苏里州1989年至1997年期间（N = 655，758）单胎出生的相关生命统计数据。采用多变量逻辑回归分析得出SGA与母亲酒精摄入量相关的校正比值比（AOR）和95%置信区间（CI）。进行了一项亚组分析，以评估饮酒和吸烟对SGA的相互作用的影响。约2%的母亲（n = 14，444）报告在怀孕期间饮酒，约4%的SGA分娩发生在这些母亲中。怀孕期间饮酒的妇女比不饮酒的妇女分娩SGA婴儿的风险高20%（AOR = 1.2; CI = 1.1-1.3）。SGA出生的相对风险随着每周饮酒量的增加而增加（趋势p <0.0001）。与饮酒但不吸烟的妇女相比，报告在怀孕期间饮酒和使用烟草制品的妇女分娩SGA婴儿的相对风险始终较高。最大的风险是那些每周吸烟和饮酒五次或五次以上的女性（AOR = 4.8，CI = 4.2-5.5）。我们的研究结果表明，产前饮酒和吸烟对分娩SGA婴儿的风险有显着的相互作用，并强调了发展“双重信息”的相关性。健康教育计划，强调怀孕期间同时接触酒精和尼古丁的有害影响。
This study investigates whether maternal cigarette smoking modifies the association between alcohol use in pregnancy and the risk of small-for-gestational-age (SGA) delivery.We employed linked vital statistics data of singleton births in the state of Missouri covering the period 1989 through 1997 (N = 655,758). Multivariate logistic regression was used to generate adjusted odds ratios (AORs) and 95% confidence intervals (CIs) for SGA associated with maternal alcohol intake. A subanalysis was conducted to assess the impact of the interaction of alcohol consumption and tobacco use on SGA.About 2% of mothers (n = 14,444) reported consuming alcohol during pregnancy, and approximately 4% of SGA births occurred among these mothers. Women who consumed alcohol during pregnancy had a 20% greater risk for delivering an SGA infant than mothers who abstained (AOR = 1.2; CI = 1.1-1.3). The relative risk for SGA birth rose as the reported number of drinks consumed per week increased (trend p < .0001). The relative risk of delivering an SGA infant was consistently higher among women who reported both drinking alcohol and using tobacco products in pregnancy as compared to women who were drinkers but nonsmokers. The greatest risk was among women who smoked and consumed five or more drinks per week (AOR = 4.8, CI = 4.2-5.5).Our findings suggest significant interaction between prenatal alcohol consumption and smoking on the risk of delivering an SGA infant and highlight the relevance of developing "dual message" health education programs that would stress the deleterious effect of joint exposure to alcohol and nicotine in pregnancy.