Relationship between dry mouth and hypertension
Relationship between dry mouth and hypertension
复制标题
口干与高血压的关系
DOI：
10.1007/s00784-021-03829-4
复制
发表时间：
2021-02-16
影响因子：
3.4
通讯作者：
Kurita, Hiroshi
中科院分区：
文献类型：
--
作者：
Kawamoto, Makiko;Yamada, Shin-ichi;Kurita, Hiroshi
目标 唾液功能障碍，例如唾液流量减少和唾液成分改变，是由多种疾病、医疗状况和药物引起的。本研究的目的是阐明高血压与颌下腺形态变化之间的关系。材料和方法进行了一项流行病学研究来阐明高血压和口干之间的关系。通过组织病理学研究高血压对下颌下腺动脉形态变化和内膜厚度的影响。结果 1933例流行病学研究对象中，155例（8.0%）有口干症状。多变量分析显示，口干与年龄 (p < 0.001)、性别 (p < 0.001) 和高血压 (p < 0.05) 相关。患有或不患有高血压的患者下颌下腺的大小没有观察到显着差异。患有高血压的患者的腺泡细胞平均面积比没有高血压的患者要小（0.366 +/- 0.153 vs. 0.465 +/- 0.178，p < 0.05）。患有高血压的患者的动脉硬化指数显着高于无高血压的患者（0.304 +/- 0.034 vs 0.475 +/- 0.053，p < 0.05）。结论高血压可能通过减少腺泡细胞数量、促进动脉脂肪浸润和狭窄而导致颌下腺变性。
Objectives Salivary dysfunction, such as reduced salivary flow and an altered salivary composition, is caused by several diseases, medical conditions, and medications. The purpose of the present study was to clarify the relationship between hypertension and morphological changes in the submandibular glands. Materials and methods An epidemiological study was conducted to elucidate the relationship between hypertension and dry mouth. The effects of hypertension on morphological changes and the intima thickness of arteries in the submandibular glands were histopathologically investigated. Results Among 1933 subjects in the epidemiological study, 155 (8.0%) had dry mouth. A multivariate analysis revealed that dry mouth correlated with age (p < 0.001), sex (p < 0.001), and hypertension (p < 0.05). No significant differences were observed in the size of the submandibular glands between patients with or without hypertension. The average area of acinar cells was smaller in patients with than in those without hypertension (0.366 +/- 0.153 vs. 0.465 +/- 0.178, p < 0.05). The arteriosclerotic index was significantly higher in patients with than in those without hypertension (0.304 +/- 0.034 vs 0.475 +/- 0.053, p < 0.05). Conclusions Hypertension may contribute to the degeneration of the submandibular glands by decreasing the number of acinar cells and promoting fatty infiltration and stenosis of the arteries.