Entrainment of the diurnal rhythm of plasma leptin to meal timing
Entrainment of the diurnal rhythm of plasma leptin to meal timing
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DOI：
10.1172/jci119717
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发表时间：
1997-10-01
影响因子：
15.9
通讯作者：
Caro, JF
中科院分区：
文献类型：
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作者：
Schoeller, DA;Cella, LK;Caro, JF
为了确定引起血浆瘦素昼夜节律的生理因素，在光/暗周期、睡眠/觉醒周期和进餐时间改变后每小时测量瘦素水平。在两个方案中的每一个方案中，研究了四名年轻男性受试者，这两个方案是模拟12小时时区移位和6.5小时进餐移位。在基线日期间，血浆瘦素表现出强的昼夜节律，振幅为21%，峰值在2400 h，最低点在0900和1200 h之间。急性睡眠剥夺不改变血浆瘦素，但昼夜颠倒（时区偏移）导致12+/-2小时的偏移（P
To identify the physiologic factor(s) that entrain the diurnal rhythm of plasma leptin, leptin levels were measured hourly after changes in light/dark cycle, sleep/wake cycle, and meal timing, Four young male subjects were studied during each of two protocols, those being a simulated 12-h time zone shift and a 6.5-h meal shift, During the baseline day, plasma leptin demonstrated a strong diurnal rhythm with an amplitude of 21%, zenith at 2400 h, and nadir between 0900 and 1200 h, Acute sleep deprivation did not alter plasma leptin, but day/night reversal (time zone shift) caused a 12+/-2 h shift (P