Carcinogenicity of dinitropyrenes in the weanling female CD rat.
Carcinogenicity of dinitropyrenes in the weanling female CD rat.
复制标题
二硝基芘对断奶雌性 CD 大鼠的致癌性。
DOI：
10.1093/carcin/12.7.1187
复制
发表时间：
1991
期刊：
影响因子：
4.7
通讯作者：
King,CM
中科院分区：
文献类型：
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作者：
Imaida,K;Lee,MS;Wang,CY;King,CM
研究了1-硝基芘和1,3-、1,6-和1,8-二硝基芘对断奶雌性CD大鼠的致癌性。实验动物按10μmol/kg体重分别腹腔或灌胃给药，每周3次，连续4周。总累积剂量平均为16μmol/只。实验在第一次给药78周后结束。1,6-和1,8-二硝基芘注射组由于几乎所有动物发生危及生命的腹膜恶性纤维组织细胞瘤（MFHs），其平均生存期分别为19周和38周。1,3-二硝基芘仅诱导少量MFHs。1,8-二硝基芘也会引起白血病的显著发生率。腹腔注射1-硝基芘、1,3-或1,8-二硝基芘组和腹腔注射1,8-二硝基芘组乳腺肿瘤的独立性显著增加。这些结果表明，硝基芘能够诱导大鼠MFH、乳腺肿瘤和白血病。
The carcinogenicities of 1-nitropyrene and 1,3-, 1,6- and 1,8-dinitropyrene were assessed in weanling female CD rats. The animals were administered one of the compounds at 10μmol/kg body wt through intraperitoneal or intragastric administration three times a week for 4 weeks. The total cumulative dose averaged 16μmol/animal. The experiment was ended 78 weeks following the first administration. The average survival period for the animals in the 1,6- and 1,8-dinitropyrene i.p. treated groups, due to the occurrence of life-threatening peritoneal malignant fibrous histiocytomas (MFHs) in nearly all of the animals, were 19 and 38 weeks respectively. 1,3-Dinitropyrene induced only a few MFHs. 1,8-Dinitropyrene also induced a significant incidence of leukemia. A significant increase of the lnddence of mammary tumors was observed in the groups of rats treated i.p. with 1-nitropyrene, or 1,3- or 1,8-dinitropyrene, and those treated i.g. with 1,8-dinitropyrene. These results demonstrate that nitropyrenes are capable of inducing MFH, mammary tumors and leukemia in the rat.