Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: A study with functional MRI
Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: A study with functional MRI
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DOI：
10.1176/ajp.156.6.891
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发表时间：
1999-06-01
影响因子：
17.7
通讯作者：
Bullmore, ET
中科院分区：
文献类型：
--
作者：
Rubia, K;Overmeyer, S;Bullmore, ET
目的：应用功能磁共振成像(MRI)技术探讨注意缺陷多动障碍(ADHD)与运动反应抑制和运动计时过程中前额脑区功能障碍的关系。方法：将7名患有ADHD的青春期男孩在执行停止任务(要求抑制计划的运动反应)和运动计时任务(要求对感觉提示的运动反应进行计时)时，将其与性别、年龄和智商相同的9名对照受试者的普通脑活动进行比较。结果：多动青少年在两种任务中均表现为右侧内侧前额叶皮质反应能力降低，停止任务时右侧前额叶下部皮质和左侧尾状回反应能力降低。结论：ADHD与负责高阶运动控制的前额叶系统异常激活有关。功能磁共振是研究ADHD神经相关因素的一种可行技术。
Objective: Functional magnetic resonance imaging (MRI) was used to investigate the hypothesis that attention deficit hyperactivity disorder (ADHD) is associated with a dysfunction of prefrontal brain regions during motor response inhibition and motor timing. Method: Generic brain activation of seven adolescent boys with ADHD was compared to that of nine comparison subjects equivalent in sex, age, and IQ while they were performing a stop task, requiring inhibition of a planned motor response, and a motor timing task, requiring timing of a motor response to a sensory cue. Results: The hyperactive adolescents showed lower power of response in the right mesial prefrontal cortex during both tasks and in the right inferior prefrontal cortex and left caudate during the stop task. Conclusions: ADHD is associated with subnormal activation of the prefrontal systems responsible for higher-order motor control. Functional MRI is a feasible technique for investigation of neural correlates of ADHD.