Efficient Regioselective Synthesis of 3‐Iodoindole N‐Carboximidamides and N‐Carboximidoates by a Sequential Aza‐Wittig/Iodine Induced Cyclization
Efficient Regioselective Synthesis of 3‐Iodoindole N‐Carboximidamides and N‐Carboximidoates by a Sequential Aza‐Wittig/Iodine Induced Cyclization
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DOI：
10.1002/cjoc.201200281
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发表时间：
2012-08
影响因子：
5.4
通讯作者：
Yi‐Bo Nie;Zhuan Duan;M. Ding
中科院分区：
文献类型：
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作者：
Yi‐Bo Nie;Zhuan Duan;M. Ding
3-从容易获得的2-炔基苯基亚氨基磷烷、异氰酸酯、各种亲核试剂和碘开始，通过连续的氮杂-维蒂希/碘诱导的环化反应，区域选择性地制备碘吲哚N-甲脒酰胺和N-甲脒酸酯4。
3-Iodoindole N-carboximidamides and N-carboximidoates 4 were prepared regioselectively via a sequential aza-Wittig/iodine induced cyclization, starting from easily accessible 2-alkynylphenyl iminophosphorane, isocyanates, various nucleophiles and iodine.