Reproductive patterns and maternal and pregnancy outcomes in women with psoriasis-A population-based study
Reproductive patterns and maternal and pregnancy outcomes in women with psoriasis-A population-based study
复制标题
DOI：
10.1016/j.jaad.2019.05.099
复制
发表时间：
2020-05-01
影响因子：
13.8
通讯作者：
Weibull, Caroline E.
中科院分区：
文献类型：
--
作者：
Lambe, Mats;Bergstrom, Anna V.;Weibull, Caroline E.
背景资料：有关银屑病女性妊娠结局的数据相互矛盾。目的：我们检查孕产妇银屑病是否影响不良孕产妇和妊娠结局的风险。方法：我们使用基于人群的数据比较患有和未患有银屑病的女性的生殖模式。估计与母亲的年龄，分娩期间，吸烟，孕前体重指数调整的比值比（OR）与95%的置信区间（CI）的不良后果：结果：与妇女无银屑病相比，银屑病妇女在第一胎较年轻，有较长的解释间隔，但没有差异，在最终的奇偶校验。银屑病妇女妊娠期高血压的风险估计值升高（OR，1.37; 95%CI，1.19 - 1.58），胎膜早破（OR，1.15; 95% CI，1.04 - 1.27），大于胎龄（OR，1.11; 95% CI，1.01 - 1.21），腭裂（OR，1.69; 95% CI，1.07 - 2.66）和未指明的畸形局限性：没有关于生活方式、疾病严重程度或治疗类型和持续时间的信息。少数人阻碍了罕见outcome.Conclusion的评估：虽然没有证据表明，生育能力受到负面影响，银屑病妇女在几个不利的孕产妇和妊娠结局的风险增加。我们的研究结果增加了越来越多的证据表明，银屑病妇女的怀孕需要特殊的监测。
Background: Data on pregnancy outcomes in women with psoriasis are conflicting.Objective: We examined whether maternal psoriasis affects the risk of adverse maternal and pregnancy outcomes.Methods: We used population-based data to compare reproductive patterns in women with and without psoriasis. Odds ratios (ORs) with 95% confidence intervals (CIs) for adverse outcomes were estimated with adjustments for maternal age, period of childbirth, smoking, and prepregnancy body mass index.Results: Compared with women without psoriasis, women with psoriasis were younger at first birth and had longer interpregnancy intervals but did not differ in final parity. Risk estimates in women with psoriasis were elevated for pregnancy hypertension (OR, 1.37; 95% CI, 1.19-1.58), premature rupture of membranes (OR, 1.15; 95% CI, 1.04-1.27), large for gestational age (OR, 1.11; 95% CI, 1.01-1.21), cleft palate (OR, 1.69; 95% CI, 1.07-2.66), and unspecified malformations (OR, 1.08; 95% CI, 1.01-1.16).Limitations: No information was available on lifestyle, disease severity, or type and duration of treatment. Small numbers hampered the assessment of rare outcomes.Conclusion: Although there was no evidence that fertility is negatively affected, women with psoriasis were at an increased risk of several adverse maternal and pregnancy outcomes. Our findings add to a growing body of evidence that pregnancies in women with psoriasis need special monitoring.