Stochastic gene expression with delay
Stochastic gene expression with delay
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DOI：
10.1016/j.jtbi.2014.09.031
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发表时间：
2015-01-07
影响因子：
2
通讯作者：
Pfaffelhuber, Peter
中科院分区：
文献类型：
--
作者：
Jansen, Martin;Pfaffelhuber, Peter
基因的表达通常遵循两个步骤。首先，基因(在基因组中编码)被转录，产生一串(信使)RNA。然后，RNA被翻译成蛋白质。我们扩展了经典随机跳跃模型，在转录和翻译中加入延迟(具有任意分布)，在经典模型中，RNA和蛋白质的产生是通过基因的激活和失活而爆发的，导致平衡的RNA和蛋白质的数量发生很大变化。在考虑平衡时滞的情况下，我们推导出了这种二阶结构的精确公式。(C)2014爱思唯尔有限公司。保留所有权利。
The expression of genes usually follows a two-step procedure. First, a gene (encoded in the genome) is transcribed resulting in a strand of (messenger) RNA. Afterwards, the RNA is translated into protein. We extend the classical stochastic jump model by adding delays (with arbitrary distributions) to transcription and translation.Already in the classical model, production of RNA and protein comes in bursts by activation and deactivation of the gene, resulting in a large variance of the number of RNA and proteins in equilibrium. We derive precise formulas for this second-order structure with the model including delay in equilibrium. (C) 2014 Elsevier Ltd. All rights reserved.