The level of typical biomarker of oxidative stress 8-hydroxy-2′-deoxyguanosine is higher in uterine myomas than in control tissues and correlates with the size of the tumor
The level of typical biomarker of oxidative stress 8-hydroxy-2′-deoxyguanosine is higher in uterine myomas than in control tissues and correlates with the size of the tumor
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DOI：
10.1016/s0891-5849(00)00358-0
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发表时间：
2000-10-01
影响因子：
7.4
通讯作者：
Olinski, R
中科院分区：
文献类型：
--
作者：
Foksinski, M;Kotzbach, R;Olinski, R
这项工作的结果表明，子宫肌瘤组织中的 8-羟基-2'-脱氧鸟苷 (8-OH-dG)（氧化应激的典型生物标志物）水平高于各自的无肿瘤组织。与绝经后女性相比，绝经前女性子宫组织中这种修饰碱基的水平升高。我们还发现了肿瘤大小与 8-OH-dG 含量之间的相关性。这些结果表明，雌激素产生的8-OH-dG可能是肌瘤形成的因素之一，并且可能有助于肌瘤细胞的恶性转化。 (C) 2000 爱思唯尔科学公司。
The results of this work show a higher level of 8-hydroxy-2 ' -deoxyguanosine (8-OH-dG), a typical biomarker of oxidative stress, in uterine myoma tissues than in their respective tumor-free tissues. The level of this modified base was elevated in uterine tissues of premenopausal women when compared with postmenopausal ones. We have also found the correlation between the size of the tumor and the amount of 8-OH-dG. These results suggest that estrogen-produced 8-OH-dG may be one of the factors responsible for the formation of the myoma, and it may contribute to malignant transformation of myoma cells. (C) 2000 Elsevier Science Inc.