Serum and urine levels of interleukin-8 in patients with non-Hodgkin's lymphoma
Serum and urine levels of interleukin-8 in patients with non-Hodgkin's lymphoma
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DOI：
10.1016/j.cyto.2008.04.004
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发表时间：
2008-07-01
期刊：
影响因子：
3.8
通讯作者：
Kong, Sun-Young
中科院分区：
文献类型：
--
作者：
Lee, Hye Lin;Eom, Hyeon-Seok;Kong, Sun-Young
血管生成在许多类型的癌症中发挥着重要作用。白介素 8 (IL-8) 已知是一种促炎和促血管生成细胞因子，据报道 IL-8 与多种癌症的肿瘤进展、预后和生存相关。然而，IL-8 在非霍奇金淋巴瘤 (NHL) 中的作用尚未完全确定。在这里，我们评估了测量 NHL 患者血清和尿液 IL-8 水平的有用性。我们为 131 名对照个体的血清和尿液 IL-8 水平制定了参考区间。我们测量了 NHL 患者的血清 IL-8 和尿液 IL-8 水平，并将其浓度与对照个体进行了比较。通过肌酐 (Cr) 校正的血清 IL-8 和尿液 IL-8 的参考区间分别为 15.9-430.3 pg/mL 和 0.0-28.4 pg/mg Cr。患者尿液 IL-8/Cr 浓度显着高于对照组（48.9 +/- 194.4 vs. 5.2 +/- 13.8 pg/mg Cr，P < 0.001）。然而，NHL 患者和对照组之间的血清 IL-8 浓度没有显着差异（159.2 +/- 40.4 与 99.6 +/- 107.1 pg/mL；P = 0.099）。接受者操作特征 (ROC) 分析得出尿液 IL-8/Cr 和血清 IL-8 的 ROC 面积值分别为 0.83 和 0.43。血清和尿液 IL-8 浓度与临床变量之间没有相关性，唯一的例外是国际预后指数 (IPI)，该指数与尿液 IL-8/Cr 水平存在边际相关性 (P = 0.07)。这项研究表明尿液 IL-8/Cr 水平可能可作为 NHL 的诊断标志物。 (C) 2008 Elsevier Ltd. 保留所有权利。
Angiogenesis plays an important role in many types of cancer. Interleukin-8 (IL-8) is known to be a proinflammatory and pro-angiogenic cytokine, and IL-8 has been reported to be associated with tumor progression, prognosis and survival in several types of cancers. However, the role of IL-8 in non-Hodgkin's lymphoma (NHL) has not been fully determined. Here, we evaluated the usefulness of measuring serum and urine IL-8 levels in patients with NHL. We developed reference intervals for serum and urine IL-8 level in 131 control individuals. We measured serum IL-8 and urine IL-8 levels in patients with NHL, and we compared the concentrations with those of control individuals. The reference intervals for serum IL-8 and urine IL-8 corrected by creatinine (Cr) were 15.9-430.3 pg/mL and 0.0-28.4 pg/mg Cr, respectively. The concentrations of urine IL-8/Cr were significantly higher in patients than in controls (48.9 +/- 194.4 vs. 5.2 +/- 13.8 pg/mg Cr, P < 0.001). However, there were no significant differences in serum IL-8 concentrations between NHL patients and controls (159.2 +/- 40.4 vs. 99.6 +/- 107.1 pg/mL; P = 0.099). Receiver operating characteristic (ROC) analysis gave 0.83 and 0.43 ROC area values for urine IL-8/Cr and serum IL-8, respectively. There was no correlation between the serum and urine concentrations of IL-8 and clinical variables, the only exception being the international prognostic index (IPI), which showed a marginal correlation with urine IL-8/Cr levels (P = 0.07). This study indicated that urine IL-8/Cr levels might be useful as a diagnostic marker of NHL. (C) 2008 Elsevier Ltd. All rights reserved.