Chronic running wheel activity attenuates the antinociceptive actions of morphine and morphine-6-glucouronide administration into the periaqueductal gray in rats
Chronic running wheel activity attenuates the antinociceptive actions of morphine and morphine-6-glucouronide administration into the periaqueductal gray in rats
复制标题
DOI：
10.1016/j.pbb.2006.03.020
复制
发表时间：
2006-04-01
影响因子：
3.6
通讯作者：
Kanarek, RB
中科院分区：
文献类型：
--
作者：
Mathes, WF;Kanarek, RB
在实验室啮齿类动物中，在跑步轮中的慢性运动增加基线疼痛敏感性，同时减弱外周给药阿片受体激动剂的抗伤害性作用。为了确定这些影响是否是由于运动引起的中枢神经系统（CNS）的变化或运动引起的外周生理学改变的伪影，本研究评价了中枢给药的阿片受体激动剂在活跃和不活跃的雌性大鼠中的抗伤害感受作用。将套管植入大鼠中脑的右侧导水管周围灰质（PAG）区域。手术完成后，允许动物自由接近转轮或在标准笼中饲养三周。在微量注射吗啡（0、2.5、5.0、10.0、20.0 μ g/大鼠）或更有效的吗啡代谢物吗啡-6-葡糖苷酸（M6 G）（0、0.03、0.1、0.3、1.0 μ g/大鼠）之前和之后立即通过甩尾试验测量疼痛敏感性。活动大鼠的基线甩尾潜伏期明显短于不活动大鼠。此外，活跃的动物比不活跃的大鼠对吗啡和M6 G的抗伤害作用不太敏感。这些发现为中枢神经系统参与运动介导的疼痛敏感性和阿片类药物作用的改变提供了证据。(c)2006年由Elsevier Inc.出版
Chronic exercise in a running wheel increases baseline pain sensitivity while attenuating the antinociceptive effects of peripherally administered opiate agonists in laboratory rodents. To determine if these effects are due to exercise-induced changes in the central nervous system (CNS) or an artifact of exercise-induced alterations in peripheral physiology, the present study evaluated the antinociceptive actions of centrally administered opiate agonists in active and inactive female rats. Rats were implanted with cannula into the right periaqueductal gray (PAG) area of the midbrain. After the completion of the surgery, the animals were allowed ad libitum access to running wheels or housed in standard cages for three weeks. Pain sensitivity was measured on the tail flick test before and immediately following microinjections of either morphine (0, 2.5, 5.0, 10.0, 20.0 mu g/rat) or the more potent morphine metabolite, morphine-6-glucuronide (M6G) (0, 0.03, 0.1, 0.3, 1.0 mu g/rat). Baseline tail flick latencies were significantly shorter in active than in inactive rats. Additionally, active animals were less sensitive to the antinociceptive effects of morphine and M6G than inactive rats. These findings provide evidence for the involvement of the CNS in exercise-mediated alterations in pain sensitivity and opiate drug actions. (c) 2006 Published by Elsevier Inc.