Visualization of specific B and T lymphocyte interactions in the lymph node
Visualization of specific B and T lymphocyte interactions in the lymph node
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DOI：
10.1126/science.281.5373.96
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发表时间：
1998-07-03
期刊：
影响因子：
56.9
通讯作者：
Jenkins, MK
中科院分区：
文献类型：
--
作者：
Garside, P;Ingulli, E;Jenkins, MK
通过在免疫后同时追踪抗原特异性CD4 T细胞和B细胞，在淋巴结中观察到了体液免疫应答的早期事件。当B细胞仍然随机分散在富含B细胞的滤泡中时，T细胞最初在T细胞区域被激活。然后这两种细胞群迁移到滤泡边缘并在那里相互作用，导致依赖CD154的B细胞增殖和生发中心形成。这些结果为同源T - B细胞相互作用提供了可视化的记录，并将其定位在滤泡边缘。
Early events in the humoral immune response were visualized in Lymph nodes by simultaneous tracking of antigen-specific CD4 T and B cells after immunization. The T cells were initially activated in the T cell areas when the B cells were still randomly dispersed in the B cell-rich follicles. Both populations then migrated to the edges of the follicles and interacted there, resulting in CD154-dependent B cell proliferation and germinal center formation. These results provide visual documentation of cognate T-B cell interactions and Localize them to the follicular border.