INVESTIGATION OF THE TUMORIGENIC RESPONSE TO BENZO(A)PYRENE IN AQUEOUS CAFFEINE SOLUTION APPLIED ORALLY TO SPRAGUE-DAWLEY RATS
INVESTIGATION OF THE TUMORIGENIC RESPONSE TO BENZO(A)PYRENE IN AQUEOUS CAFFEINE SOLUTION APPLIED ORALLY TO SPRAGUE-DAWLEY RATS
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DOI：
10.1007/bf00410666
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发表时间：
1981-01-01
影响因子：
3.6
通讯作者：
SCHMAHL, D
中科院分区：
文献类型：
--
作者：
BRUNE, H;DEUTSCHWENZEL, RP;SCHMAHL, D
在一项终生实验中，将苯并（a）芘（B（a）P）作为饮食混合物或通过灌胃法在1.5%咖啡因水溶液中给予Sprague-Dawley大鼠。溶解的苯并（a）芘比未溶解的苯并（a）芘诱发更多的前胃肿瘤。在本生物测定条件下，1.5%咖啡因溶液（年剂量27 g/kg）未产生任何致癌活性。
In a lifetime experiment benzo(a)pyrene (B(a)P) was administered to Sprague-Dawley rats either as an admixture to the diet or by gavage in an aqueous 1.5% caffeine solution. Dissolved benzo(a)pyrene induced more tumors of the forestomach than undissolved benzo(a)pyrene. The 1.5% caffeine solution (annual dose 27 g/kg) did not exert any carcinogenic activity under the conditions of this bioassay.