Changes of brain resting state functional connectivity predict the persistence of cognitive rehabilitation effects in patients with multiple sclerosis
Changes of brain resting state functional connectivity predict the persistence of cognitive rehabilitation effects in patients with multiple sclerosis
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DOI：
10.1177/1352458513505692
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发表时间：
2014-05-01
影响因子：
5.8
通讯作者：
Filippi, Massimo
中科院分区：
文献类型：
--
作者：
Parisi, Laura;Rocca, Maria A.;Filippi, Massimo
目的：我们调查了MS患者12周的认知康复治疗的疗效是否持续6个月后，治疗终止，连同静息状态（RS）功能连接（FC），在follow-up.Methods的神经心理学性能的变化：18 MS患者的认知缺陷，随机分配到接受治疗（n=9）或不（n=9），进行神经心理学评估在基线（t0），12周的康复（t1）后，在6个月的随访（t2）。在t0和t1时获得RS fMRI。在神经心理学性能的变化及其与RS FC修改的相关性进行了评估，使用纵向线性models.Results：在t2与t0，与对照组相比，治疗组患者的注意力，执行功能，抑郁症和生活质量（QoL）的测试改善。在t2这些测试中的神经心理学评分与认知相关网络中的RS FC变化和前扣带的RS FC显著相关。RS FC的变化在默认模式网络预测的认知性能和严重程度较低的抑郁症，而RS FC的变化的执行网络预测更好的QoL.Discussion：RS FC的认知相关的网络的变化有助于解释的持久性认知康复的影响后几个月复发缓解型多发性硬化症患者和他们的抑郁症和生活质量量表的改善。
Objective:We investigated whether the efficacy of 12-week cognitive rehabilitation in MS patients persists six months after treatment termination and, together with resting state (RS) functional connectivity (FC), changes on neuropsychological performance at follow-up.Methods:Eighteen MS patients with cognitive deficits, assigned randomly either to undergo treatment (n=9) or not (n=9), underwent neuropsychological evaluation at baseline (t0), after 12 weeks of rehabilitation (t1) and at six-month follow-up (t2). RS fMRI was obtained at t0 and t1. Changes in neuropsychological performance and their correlations with RS FC modifications were assessed using longitudinal linear models.Results:At t2 vs. t0, compared with the control group, treated group patients improved in tests of attention, executive function, depression and quality of life (QoL). Neuropsychological scores in these tests at t2 were significantly correlated with RS FC changes in cognitive-related networks and RS FC of the anterior cingulum. RS FC changes in the default mode network predicted cognitive performance and less severe depression, whereas RS FC changes of the executive network predicted better QoL.Discussion:Changes in RS FC of cognitive-related networks helps to explain the persistence of the effects of cognitive rehabilitation after several months in relapsing-remitting multiple sclerosis patients and their improvement on depression and QoL scales.