Brain metabolites as 1H NMR markers of neuronal and glial disorders.
Brain metabolites as 1H NMR markers of neuronal and glial disorders.
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DOI：
10.1002/nbm.1940020505
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发表时间：
1989-12-01
影响因子：
2.9
通讯作者：
Williams, S R
中科院分区：
文献类型：
--
作者：
Gill, S S;Small, R K;Williams, S R
在体人脑的1H NMR光谱可用于检测许多脑代谢物，包括N-乙酰天冬氨酸、肌酸+磷酸肌酸和含胆碱化合物。我们已经使用1H NMR光谱分析这些信号在（i）活检材料从正常人脑和星形细胞瘤，和（ii）原代星形胶质细胞培养。在此分析的基础上，我们得出结论，在体内1H NMR光谱可以发挥重要的临床作用，在非侵入性评估神经元变性和非神经元细胞增殖。
1H NMR spectroscopy of human brain in vivo can be used to detect a number of cerebral metabolites including N-acetylaspartate, creatine + phosphocreatine and choline-containing compounds. We have used 1H NMR spectroscopy to analyse these signals in (i) biopsy material from both normal human brain and astrocytomas, and (ii) primary astrocyte cultures. On the basis of this analysis, we conclude that in vivo 1H NMR spectroscopy could play an important clinical role in the non-invasive assessment of neuronal degeneration and proliferation of non-neuronal cells.