Psychological impact of genetic and clinical screening for pulmonary fibrosis on asymptomatic first-degree relatives of affected individuals.
Psychological impact of genetic and clinical screening for pulmonary fibrosis on asymptomatic first-degree relatives of affected individuals.
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DOI：
10.1136/thoraxjnl-2020-216244
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发表时间：
2021-06
期刊：
影响因子：
10
通讯作者：
Raby BA
中科院分区：
文献类型：
--
作者：
Carmichael N;Martinez Manzano JM;Quesada-Arias LD;Poli SF;Baumgartner MA;Planchart Ferretto MA;DiGianni L;Gampala-Sagar S;Leone DA;Gulati S;El-Chemaly SY;Goldberg HJ;Putman R;Hatabu H;Rosas IO;Hunninghake GM;Raby BA
肺纤维化筛查可能有助于识别疾病的早期阶段。我们在参与者收到结果后，通过实施两个有效的测量来评估筛查未确诊的肺纤维化患者一级亲属的心理影响：决策后悔量表(DRS)和对基因组检测结果的感受(因素)问卷。超过90%的亲属表示没有或有轻微的决定后悔。在那些发现DLCO低或间质肺异常的患者中，决策悔恨和消极情绪的测量增加。端粒长度和基因检测的结果对后悔没有显著影响。
Screening for pulmonary fibrosis may help to identify early stages of the disease. We assessed the psychological impact of screening undiagnosed first-degree relatives of patients with pulmonary fibrosis by administering two validated measures after participants received their results: the Decisional Regret Scale (DRS) and the Feelings About genomiC Testing Results (FACToR) Questionnaire. More than 90% of relatives reported either no or mild decisional regret. Increased measures of decisional regret and negative feelings were present in those found to have a low DLCO or interstitial lung abnormalities. Results of telomere length and genetic testing did not significantly impact regret.
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影响因子：
3.6
作者：
Brehaut, JC;O'Connor, AM;Feldman-Stewart, D
通讯作者：
Feldman-Stewart, D
影响因子：
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作者：
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Boyages, John
DOI：
10.1164/rccm.201908-1571oc
发表时间：
2020-05-15
影响因子：
24.7
作者：
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通讯作者：
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作者：
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影响因子：
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作者：
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通讯作者：
Patrick, Donald L.