Cationic Ruthenium(II) Catalysts for Oxidative C-H/N-H Bond Functionalizations of Anilines with Removable Directing Group: Synthesis of Indoles in Water
Cationic Ruthenium(II) Catalysts for Oxidative C-H/N-H Bond Functionalizations of Anilines with Removable Directing Group: Synthesis of Indoles in Water
复制标题
DOI：
10.1021/ol203309y
复制
发表时间：
2012-02-03
期刊：
影响因子：
5.2
通讯作者：
Lygin, Alexander V.
中科院分区：
文献类型：
--
作者：
Ackermann, Lutz;Lygin, Alexander V.
阳离子钌（II）配合物使含可移动导向基团的苯胺氧化C-H键功能化。C-H/N-H键的断裂在水这种可持续溶剂中发生得最有效，并且为各种生物活性吲哚提供了普遍的途径。机理研究为新型反应歧管的建立提供了有力的支持。
Cationic ruthenium(II) complexes enabled oxidative C-H bond functionalizations with anilines bearing removable directing groups. The C-H/N-H bond cleavages occurred most efficiently in water as a sustainable solvent and provided general access to various bioactive indoles. Mechanistic studies provided strong support for a novel reaction manifold.