Type 2 diabetes and cognitive impairment: contributions from neuroimaging.
Type 2 diabetes and cognitive impairment: contributions from neuroimaging.
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DOI：
10.1177/0891988713516543
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发表时间：
2014-03
影响因子：
2.6
通讯作者：
Rosano C
中科院分区：
文献类型：
--
作者：
Ryan JP;Fine DF;Rosano C
2型糖尿病(T2D)和阿尔茨海默病(AD)是与老龄化相关的主要公共卫生负担。随着人口年龄的迅速增长，这些疾病的发病率预计会急剧增加。研究已经确定T2D是认知障碍和潜在的AD的风险因素，但受影响的神经生物学途径才刚刚开始被了解。在过去的十年里，神经成像的快速发展增加了人们对T2D如何影响大脑结构和功能并可能导致AD的重要了解。本文对利用结构和功能神经成像来确定T2D与认知能力受损和潜在的AD的神经通路的研究进行了综述。这篇文章的主要焦点是神经成像的潜力，以帮助理解可能为临床干预提供翻译机会的机制路径。
Type 2 diabetes mellitus (T2D) and Alzheimer’s disease (AD) are major public health burdens associated with aging. As the age of the population rapidly increases, a sheer increase in the incidence of these diseases is expected. Research has identified T2D as a risk factor for cognitive impairment and potentially AD, but the neurobiological pathways that are affected are only beginning to be understood. The rapid advances in neuroimaging in the past decade have added significant understanding to how T2D affects brain structure and function and possibly lead to AD. This article provides a review of studies that have utilized structural and functional neuroimaging to identify neural pathways that link T2D to impaired cognitive performance and potentially AD. A primary focus of this article is the potential for neuroimaging to assist in understanding the mechanistic pathways that may provide translational opportunities for clinical intervention.
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作者：
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DOI：
10.1093/gerona/60.4.471
发表时间：
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影响因子：
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通讯作者：
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