Central role of arachidonate 5-lipoxygenase in the regulation of cell growth and apoptosis in human prostate cancer cells.
Central role of arachidonate 5-lipoxygenase in the regulation of cell growth and apoptosis in human prostate cancer cells.
复制标题
花生四烯酸 5-脂氧合酶在调节人前列腺癌细胞的细胞生长和凋亡中的核心作用。
DOI：
10.1007/978-1-4615-4793-8_84
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发表时间：
1999
影响因子：
--
通讯作者：
Myers,CE
中科院分区：
文献类型：
--
作者：
Ghosh,J;Myers,CE
饮食脂肪和前列腺癌的风险：前列腺癌已成为美国男性中最常见的恶性肿瘤，每年夺走数千人的生命（1）。这是一种多步骤的疾病。在美国，虽然有超过1500万男性患有局限性前列腺癌，但在给定的一年中，只有40- 50，000名男性会发展为恶性肿瘤并死亡。因此，转移表型的发展是前列腺癌自然史中重要的限速步骤。通过潜伏形式的疾病在世界范围内的发病率相同，在临床证据前列腺癌的诊断和死亡率方面存在显著的地理差异（2-4），表明环境因素参与了这一过程。此外，从低发病率国家迁移到高发病率国家的人显示浸润性前列腺癌的风险增加（5-8），表明生活方式因素（如饮食和营养）的积极作用。
Dietary fat and the risk of prostate cancer: Prostate cancer has emerged as the most frequently diagnosed malignancy among men in the United States, taking thousands of lives every year (1). It is a multistep disease. In the United States, while there are more than 15 million men with localized prostate cancer, only 40–50,000 men will develop malignancy and die in a given year. Thus the development of the metastatic phenotype is an important rate limiting step in the natural history of prostate cancer. Through the incidence of the latent form of the diseases the same worldwide, there is significant geographic variation in the diagnosis of clinically evidence prostate cancer and mortality (2–4) suggesting involvement of environmental factors in this process. Moreover, people who migrate from low-incidence countries to high-incidence countries show increased risk of invasive prostate cancer (5–8) indicating a positive role for lifestyle factors, such as diet and nutrition.